Moghaddasnejad Mohammad Reza, Keshavarz Ali, Mardi Amirhossein, Sherafat Negar Sadat, Aghebati-Maleki Leili, Mohammadi Mohammad Hossein
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, P.O.Box: 15468-15514, Tehran, Iran.
Mol Biol Rep. 2025 May 8;52(1):449. doi: 10.1007/s11033-025-10513-3.
Long non-coding RNAs (lncRNAs) have emerged as critical regulators in cancer biology, particularly in the modulation of innate immune cells within the tumor microenvironment. These lncRNAs significantly influence the phenotype and function of immune cells, such as tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), dendritic cells (DCs), natural killer cells (NK), neutrophils, and γδT cells. Thus, lncRNAs emerge as pivotal molecules in cancer development due to their capacity to modulate the innate immune system. Understanding the intricate mechanisms by which lncRNAs influence tumor-associated immune cells can pave the way for novel therapeutic strategies to restore effective anti-tumor immunity. This review highlights the diverse roles of lncRNAs in regulating the differentiation, activation, and effector functions of innate immune cells within the complex tumor microenvironment.
长链非编码RNA（lncRNAs）已成为癌症生物学中的关键调节因子，尤其是在肿瘤微环境中对固有免疫细胞的调节方面。这些lncRNAs显著影响免疫细胞的表型和功能，如肿瘤相关巨噬细胞（TAMs）、髓系来源的抑制细胞（MDSCs）、树突状细胞（DCs）、自然杀伤细胞（NK）、中性粒细胞和γδT细胞。因此，lncRNAs因其调节固有免疫系统的能力而成为癌症发展中的关键分子。了解lncRNAs影响肿瘤相关免疫细胞的复杂机制可为恢复有效的抗肿瘤免疫的新治疗策略铺平道路。本综述强调了lncRNAs在复杂肿瘤微环境中调节固有免疫细胞的分化、激活和效应功能方面的多种作用。
