Tabacu Carmen, Manolea Maria-Magdalena, Dijmarescu Anda Lorena, Şerbanescu Mircea-Sebastian, Boldeanu Mihail Virgil, Novac Liliana
Doctoral School, University of Medicine and Pharmacology of Craiova, Romania.
Obstetrics and Gynecology Department, University of Medicine and Pharmacology of Craiova, Romania.
Curr Health Sci J. 2021 Jul-Sep;47(3):428-432. doi: 10.12865/CHSJ.47.03.14. Epub 2021 Sep 30.
Higher serum leptin values have been correlated with several complications of pregnancy, while the abdominal circumference (AC) is an anthropometric measurement usually used to diagnose abdominal obesity. For this study we compared serum leptin levels between two groups of pregnant women: those with abdominal obesity (AC>88cm) and those without abdominal obesity (AC<88cm), diagnosed at the beginning of pregnancy. Serum leptin levels were obtained through measurements performed between 11-14 and 28-32 weeks of gestation. Higher serum leptin levels were found in the group of pregnant women with abdominal obesity comparing to the group without abdominal obesity, but a positive correlation between abdominal circumference and the leptin values was found only at 11-14 weeks of pregnancy. Our study showed that a simple measurement of AC performed at the beginning of pregnancy may predict the average serum levels of leptin throughout the gestation period. A better understanding of the role of leptin during development is needed to make us able to know how maternal-placental-fetal leptin exchange influence the fetal development.
较高的血清瘦素水平与多种妊娠并发症相关，而腹围（AC）是一种通常用于诊断腹部肥胖的人体测量指标。在本研究中，我们比较了两组孕妇的血清瘦素水平：妊娠初期诊断为腹部肥胖（腹围>88cm）的孕妇和无腹部肥胖（腹围<88cm）的孕妇。血清瘦素水平通过在妊娠11 - 14周和28 - 32周期间进行的测量获得。与无腹部肥胖的孕妇组相比，腹部肥胖的孕妇组血清瘦素水平更高，但仅在妊娠11 - 14周时发现腹围与瘦素值之间存在正相关。我们的研究表明，在妊娠初期进行的简单腹围测量可能预测整个妊娠期的平均血清瘦素水平。为了能够了解母-胎-胎盘瘦素交换如何影响胎儿发育，需要更好地理解瘦素在发育过程中的作用。
