Deepika Velusami, Preethy Perumal
Department of Physiology, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry, India.
III Year MBBS, Department of Physiology, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry, India.
Curr Health Sci J. 2021 Jul-Sep;47(3):433-437. doi: 10.12865/CHSJ.47.03.15. Epub 2021 Sep 30.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder. It is a multi-factorial disease, of which excess androgen and android fat pattern is previously reported. The digit ratio (2D:4D) is the ratio of length of index finger to the length of ring finger which epitomize the prenatal gonadal hormone exposure. So, the present study aimed to evaluate body fat composition and digit ratio among young adolescent PCOS patients and normal individuals. It was an analytical cross-sectional study. Based on the inclusion and exclusion criteria, 48 subjects (24 in each group), that is, control and PCOS group were identified and baseline characteristics were recorded. Body fat composition was evaluated using body fat analyzer and digit ratio (2D:4D) was measured using the digital Vernier calipers. Student's t-test was used to assess differences between means. In the present study, BMI was significantly increased among the PCOS group compared to the normal (p=0.03). The 2D:4D digit ratio was significantly lower (p=0.001) among the PCOS group. Body fat (p=0.05) and visceral fat (p=0.01) were significantly higher among the PCOS group. There was negative correlation between BMI, body fat, visceral fat and digit ratio, but was not statistically significant while body fat, visceral fat and BMI showed significant positive correlation. The present study indicates that the 2D:4D digit ratio is decreased, while BMI, body fat and visceral fat are significantly increased among the PCOS group. Digit ratio and body fat can be used to evaluate the high risk PCOS adolescents and plan early interventions.
多囊卵巢综合征（PCOS）是一种常见的内分泌紊乱疾病。它是一种多因素疾病，此前已有报道称其存在雄激素过多和男性化脂肪分布模式。指长比（2D:4D）是食指长度与无名指长度的比值，它体现了产前性腺激素暴露情况。因此，本研究旨在评估年轻青春期PCOS患者和正常个体的体脂成分及指长比。这是一项分析性横断面研究。根据纳入和排除标准，确定了48名受试者（每组24名），即对照组和PCOS组，并记录了基线特征。使用体脂分析仪评估体脂成分，使用数字游标卡尺测量指长比（2D:4D）。采用学生t检验评估均值之间的差异。在本研究中，与正常组相比，PCOS组的BMI显著升高（p=0.03）。PCOS组的2D:4D指长比显著更低（p=0.001）。PCOS组的体脂（p=0.05）和内脏脂肪（p=0.01）显著更高。BMI、体脂、内脏脂肪与指长比之间呈负相关，但无统计学意义，而体脂、内脏脂肪与BMI呈显著正相关。本研究表明，PCOS组的2D:4D指长比降低，而BMI、体脂和内脏脂肪显著增加。指长比和体脂可用于评估PCOS高危青少年并制定早期干预措施。
