Division of Nutritional Sciences, College of Agriculture of Life Sciences, Ithaca, NY 14853, USA.
Reprod Biol Endocrinol. 2010 Dec 29;8:156. doi: 10.1186/1477-7827-8-156.
We recently showed that women with four clinical phenotypes of polycystic ovary syndrome (PCOS) do not demonstrate anatomical evidence of elevated prenatal androgen exposure as judged by a lower ratio of the index (2D) to ring (4D) finger. However, those findings conflicted with a previous study where women with PCOS had lower right hand 2D:4D compared to healthy female controls. Both these studies used Vernier calipers to measure finger lengths--a method recently shown to be less reliable at obtaining finger length measurements than computer-assisted analysis.
Ninety-six women diagnosed with PCOS according to the 2003 Rotterdam criteria had their finger lengths measured with computer-assisted analysis. Participants were categorized into four recognized phenotypes of PCOS and their 2D:4D compared to healthy female controls (n = 48) and men (n = 50).
Digit ratios assessed by computer-assisted analysis in women with PCOS did not differ from female controls, but were significantly lower in men. When subjects were stratified by PCOS phenotype, 2D:4D did not differ among phenotypes or when compared to female controls.
Computer-assisted measurements validated that digit ratios of women with PCOS do not show anatomical evidence of increased prenatal androgen exposure.
我们最近发现，四种多囊卵巢综合征（PCOS）临床表型的女性并没有表现出产前雄激素暴露升高的解剖学证据，这可以通过较低的食指（2D）与环指（4D）比值来判断。然而，这些发现与之前的一项研究结果相矛盾，该研究表明 PCOS 女性的右手 2D:4D 比值低于健康女性对照组。这两项研究都使用游标卡尺来测量手指长度——最近的研究表明，这种方法在获取手指长度测量值方面不如计算机辅助分析可靠。
根据 2003 年鹿特丹标准诊断为 PCOS 的 96 名女性使用计算机辅助分析测量其手指长度。将参与者分为四个公认的 PCOS 表型，并将其 2D:4D 与健康女性对照组（n = 48）和男性（n = 50）进行比较。
PCOS 女性的计算机辅助分析评估的数字比值与女性对照组没有差异，但明显低于男性。当根据 PCOS 表型对受试者进行分层时，各表型之间或与女性对照组相比，2D:4D 均无差异。
计算机辅助测量验证了 PCOS 女性的数字比值没有表现出增加的产前雄激素暴露的解剖学证据。
