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短期暴露于高相对湿度会通过改变肠道微生物群来增加血尿素，并影响结肠尿素氮代谢。

Short-term exposure to high relative humidity increases blood urea and influences colonic urea-nitrogen metabolism by altering the gut microbiota.

机构信息

State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, 235 Nanjing East Road, Nanchang 330047, China.

The College of National Land Resource and Environment, Jiangxi Agriculture University, Nanchang, Jiangxi 330045, China.

出版信息

J Adv Res. 2021 Mar 15;35:153-168. doi: 10.1016/j.jare.2021.03.004. eCollection 2022 Jan.

DOI:10.1016/j.jare.2021.03.004
PMID:35003799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8721250/
Abstract

INTRODUCTION

Colonic urea-nitrogen metabolites have been implicated in the pathogenesis of certain diseases which can be affected by environmental factors.

OBJECTIVES

We aimed to explore the influence of ambient humidity on colonic urea-nitrogen metabolism.

METHODS

Blood biochemical indexes, metabolites of intestinal tract, and gut microbiota composition of mice ( = 10/group) exposed to high relative humidity (RH, 90 ± 2%) were analyzed during the 14-day exposure.

RESULTS

After 12-h exposure, plasma blood urea nitrogen (BUN) level increased along with a decrease in the activity of erythrocyte Na/K -ATPase. Moreover, abnormal erythrocyte morphologies appeared after 3 days of exposure. The colonic BUN and ammonia levels increased significantly after the 12-h and 24-h exposure, respectively. The colonic level of amino acids, partly synthesized by gut microbiota using ammonia as the nitrogen source, was significantly higher on the 7th day. Furthermore, the level of fecal short-chain fatty acids was significantly higher after 3-day exposure and the level of branched-chain fatty acids increased on the 14th day. Overall, gut microbiota composition was continuously altered during exposure, facilitating the preferential proliferation of urea-nitrogen metabolism bacteria.

CONCLUSION

Our findings suggest that short-term high RH exposure influences colonic urea-nitrogen metabolism by increasing the influx of colonic urea and altering gut microbiota, which might further impact the host health outcomes.

摘要

简介

肠道尿素氮代谢物与某些受环境因素影响的疾病的发病机制有关。

目的

我们旨在探讨环境湿度对肠道尿素氮代谢的影响。

方法

分析了在 14 天暴露期间，暴露于高相对湿度（RH，90±2%）下的小鼠（每组 10 只）的血液生化指标、肠道代谢物和肠道微生物群落组成。

结果

暴露 12 小时后，血浆血尿素氮（BUN）水平升高，同时红细胞 Na/K-ATP 酶活性下降。此外，暴露 3 天后出现异常的红细胞形态。暴露 12 小时和 24 小时后，结肠 BUN 和氨水平分别显著升高。肠道中由肠道微生物部分合成的氨基酸水平在第 7 天显著升高。此外，粪便短链脂肪酸水平在 3 天暴露后显著升高，支链脂肪酸水平在第 14 天升高。总的来说，暴露期间肠道微生物群落组成不断改变，有利于优先增殖尿素氮代谢细菌。

结论

我们的研究结果表明，短期高 RH 暴露通过增加肠道尿素的流入和改变肠道微生物群来影响肠道尿素氮代谢，这可能进一步影响宿主的健康结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7976/8721250/6b46ac87d89d/gr12.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7976/8721250/ca320b7b6c5b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7976/8721250/88f1d8c609ab/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7976/8721250/5586132bcbd3/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7976/8721250/8619babcc4cd/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7976/8721250/83d1c394d0fc/gr10.jpg
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