Moretti J L, Cinotti L, Cesaro P, Defer G, Joulin Y, Sergent A, Vigneron N, Rapin J R, Raynaud C
Départment of Neurosciences, Creteil, France.
Nucl Med Commun. 1987 Jul;8(7):581-95.
Amines like N-isopropyl-p-123I-iodoamphetamine (IMP) and hydroxy 123I-iodobenzyl propyl diamine (HIPDM) associated with brain tomoscintigraphy have proved their worth for detecting ischaemic abnormalities. Even though the chemistry of their metabolism and their biodistribution are not fully understood, their application in the study of parenchymal impairment in stroke and reversible ischaemia yields additional information compared to the other methods of imaging like CT or MRI. The concept of a steady state in brain with a wash in/wash out model has been considered especially with IMP, to explain the evolution of the activity pattern with time when comparing early and delayed images. (This review leads to foresee the prognosis of of ischaemic diseases when redistribution is taken into account.)
像 N-异丙基-p-123I-碘安非他明（IMP）和羟基 123I-碘苄基丙二胺（HIPDM）这类与脑断层闪烁扫描相关的胺类物质，已证明其在检测缺血性异常方面的价值。尽管它们的代谢化学和生物分布尚未完全明确，但与 CT 或 MRI 等其他成像方法相比，它们在中风和可逆性缺血的实质损伤研究中的应用能提供更多信息。特别是对于 IMP，人们考虑了脑内稳态及洗入/洗出模型的概念，以解释在比较早期和延迟图像时活性模式随时间的演变。（当考虑到再分布时，这篇综述有助于预测缺血性疾病的预后。）
