威斯康星糖尿病视网膜病变流行病学研究。VII. 糖尿病性非增殖性视网膜病变

The Wisconsin Epidemiologic Study of Diabetic Retinopathy. VII. Diabetic nonproliferative retinal lesions.

作者信息

Klein R, Klein B E, Moss S E, Davis M D, DeMets D L

机构信息

Department of Ophthalmology, University of Wisconsin Medical School, Madison 53792.

出版信息

Ophthalmology. 1987 Nov;94(11):1389-400. doi: 10.1016/s0161-6420(87)33275-0.

DOI:10.1016/s0161-6420(87)33275-0

PMID:3500443

Abstract

The prevalences of hard exudates, soft exudates, intraretinal microvascular abnormalities (IRMAs), and venous beading and their relationships to demographic and other characteristics were examined in a population-based study in southern Wisconsin. For participants whose age at diagnosis was less than 30 years and who were taking insulin (N = 996), hard exudates were found in 24.2%, soft exudates in 15.3%, IRMAs in 16.5%, and venous beading in 7.0% of the population. For participants whose age at diagnosis was 30 years or older and who were taking insulin (N = 674), hard exudates were found in 28.3%, soft exudates in 15.5%, IRMAs in 8.8%, and venous beading in 3.2%. For older-onset persons not taking insulin (N = 696), hard exudates were found in 9.4%, soft exudates in 5.4%, IRMAs in 2.6%, and venous beading in 0.9% of the population. The severities of the lesions were found to be consistently associated with longer duration of diabetes in younger-onset persons and the presence of proteinuria in older-onset persons.

摘要

在威斯康星州南部进行的一项基于人群的研究中，对硬性渗出、软性渗出、视网膜内微血管异常（IRMA）和静脉串珠样改变的患病率及其与人口统计学和其他特征的关系进行了研究。对于诊断时年龄小于30岁且正在使用胰岛素的参与者（N = 996），该人群中硬性渗出的发生率为24.2%，软性渗出为15.3%，IRMA为16.5%，静脉串珠样改变为7.0%。对于诊断时年龄为30岁及以上且正在使用胰岛素的参与者（N = 674），硬性渗出的发生率为28.3%，软性渗出为15.5%，IRMA为8.8%，静脉串珠样改变为3.2%。对于未使用胰岛素的晚发型患者（N = 696），该人群中硬性渗出的发生率为9.4%，软性渗出为5.4%，IRMA为2.6%，静脉串珠样改变为0.9%。发现病变的严重程度与早发型患者较长的糖尿病病程以及晚发型患者蛋白尿的存在始终相关。