威斯康星糖尿病视网膜病变流行病学研究。青年发病与老年发病糖尿病患者视网膜病变的比较。

The Wisconsin Epidemiologic Study of Diabetic Retinopathy. A comparison of retinopathy in younger and older onset diabetic persons.

作者信息

Klein R, Davis M D, Moss S E, Klein B E, DeMets D L

出版信息

Adv Exp Med Biol. 1985;189:321-35. doi: 10.1007/978-1-4757-1850-8_18.

Abstract

In a population-based survey of diabetic persons, retinopathy was detected by stereoscopic color fundus photography in 70% of persons under 30 years of age at diagnosis and taking insulin (Group YO), in 62% of persons 30 years of age or older at diagnosis and taking insulin (Group OO-I) and in 36% of persons 30 years of age or older at diagnosis not taking insulin (Group OO-N). The mean duration of known diabetes was 14.6 years in Group YO, 11.0 years in Group OO-I and 6.9 years in Group OO-N. After 20 years of diabetes, proliferative retinopathy was present in about 50% of Group YO, about 25% of Group OO-I and about 5% of Group OO-N. After 15 years of diabetes, macular edema was present in about 18% of Group YO, about 20% of Group OO-I and about 12% of Group OO-N. When present, macular edema tended to be associated with more hard exudate in Group OO-N.

摘要

在一项基于人群的糖尿病患者调查中，通过立体彩色眼底照相术检测到，在诊断时年龄小于30岁且正在接受胰岛素治疗的患者中（YO组），视网膜病变的检出率为70%；在诊断时年龄为30岁及以上且正在接受胰岛素治疗的患者中（OO-I组），检出率为62%；在诊断时年龄为30岁及以上且未接受胰岛素治疗的患者中（OO-N组），检出率为36%。YO组已知糖尿病的平均病程为14.6年，OO-I组为11.0年，OO-N组为6.9年。糖尿病病程达20年后，YO组约50%出现增殖性视网膜病变，OO-I组约25%，OO-N组约5%。糖尿病病程达15年后，YO组约18%出现黄斑水肿，OO-I组约20%，OO-N组约12%。OO-N组出现黄斑水肿时，往往伴有更多硬性渗出。