Wang Xiaoyan, Li Xingming, Jin Chunhua, Bai Xinyuan, Qi Xinran, Wang Jianhong, Zhang Lili, Li Na, Jin Na, Song Wenhong, Gao Haitao, Gao Baojun, Zhang Yue, Wang Lin
Department of Children Health Care, Capital Institute of Pediatrics, Beijing, China.
School of Public Health, Capital Medical University, Beijing, China.
Front Pediatr. 2021 Dec 24;9:756217. doi: 10.3389/fped.2021.756217. eCollection 2021.
To evaluate the association between serum vitamin A levels and the prevalence of recurrent respiratory tract infections (RRTIs) in children and adolescents and to provide evidence that would help decrease the prevalence of respiratory tract infections (RTIs) in children. This cross-sectional study included 8034 children and adolescents in Beijing aged 6 months to 17 years. RRTI and RTI symptoms were diagnosed according to the . Multivariate logistic regression models were used to evaluate the association between serum vitamin A levels and RRTIs after adjusting for potential confounders. Among the included children, 721 (8.97%) were diagnosed with vitamin A deficiency, whereas 3,073 (38.25%) were diagnosed with subclinical vitamin A deficiency. Only 28.8% (208/721) of children with vitamin A deficiency and 53.1% (1,631/3,073) of children with subclinical vitamin A deficiency had no RRTI and RTI symptoms, respectively. Compared with children with normal vitamin A levels, those with vitamin A deficiency and subclinical vitamin A deficiency had a greater risk for RRTIs, with an odds ratio (OR) of 6.924 [95% confidence interval (CI): 5.433-8.824] and 2.140 (95% CI: 1.825-2.510), respectively]. Vitamin A levels were also positively associated with RTI symptoms, with those having vitamin A deficiency and subclinical vitamin A deficiency showing an OR of 1.126 (95% CI: 0.773-1.640) and 1.216 (95% CI: 1.036-1.427), respectively. The present cross-sectional study found that low serum vitamin A levels were significantly associated with RRTI or RTI prevalence in children and adolescents.
评估儿童和青少年血清维生素A水平与反复呼吸道感染（RRTIs）患病率之间的关联，并提供有助于降低儿童呼吸道感染（RTIs）患病率的证据。这项横断面研究纳入了8034名年龄在6个月至17岁的北京儿童和青少年。RRTI和RTI症状根据……进行诊断。多因素逻辑回归模型用于在调整潜在混杂因素后评估血清维生素A水平与RRTIs之间的关联。在所纳入的儿童中，721名（8.97%）被诊断为维生素A缺乏，而3073名（38.25%）被诊断为亚临床维生素A缺乏。维生素A缺乏的儿童中只有28.8%（208/721）没有RRTI症状，亚临床维生素A缺乏的儿童中只有53.1%（1631/3073）没有RTI症状。与维生素A水平正常的儿童相比，维生素A缺乏和亚临床维生素A缺乏的儿童患RRTIs的风险更高，优势比（OR）分别为6.924 [95%置信区间（CI）：5.433 - 8.824]和2.140（95% CI：1.825 - 2.510）。维生素A水平也与RTI症状呈正相关，维生素A缺乏和亚临床维生素A缺乏的儿童的OR分别为1.126（95% CI：0.773 - 1.640）和1.216（95% CI：1.036 - 1.427）。这项横断面研究发现，儿童和青少年血清维生素A水平低与RRTI或RTI患病率显著相关。
