Zhao Yan, Liu You-Shuo
Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Institute of Aging and Age-Related Disease Research, Central South University, Changsha, China.
Front Cardiovasc Med. 2021 Dec 23;8:778674. doi: 10.3389/fcvm.2021.778674. eCollection 2021.
Forkhead box O3 (FOXO3) has been proposed as a homeostasis regulator, capable of integrating multiple upstream signaling pathways that are sensitive to environmental changes and counteracting their adverse effects due to external changes, such as oxidative stress, metabolic stress and growth factor deprivation. FOXO3 polymorphisms are associated with extreme human longevity. Intriguingly, longevity-associated single nucleotide polymorphisms (SNPs) in human correlate with lower-than-average morbidity from cardiovascular diseases in long-lived people. Emerging evidence indicates that FOXO3 plays a critical role in vascular aging. FOXO3 inactivation is implicated in several aging-related vascular diseases. In experimental studies, FOXO3-engineered human ESC-derived vascular cells improve vascular homeostasis and delay vascular aging. The purpose of this review is to explore how FOXO3 regulates vascular aging and its crucial role in aging-related vascular diseases.
叉头框O3（FOXO3）被认为是一种体内平衡调节因子，能够整合多个对环境变化敏感的上游信号通路，并抵消由于外部变化（如氧化应激、代谢应激和生长因子剥夺）而产生的不利影响。FOXO3基因多态性与人类的极端长寿有关。有趣的是，人类中与长寿相关的单核苷酸多态性（SNP）与长寿人群中低于平均水平的心血管疾病发病率相关。新出现的证据表明，FOXO3在血管衰老中起关键作用。FOXO3失活与几种与衰老相关的血管疾病有关。在实验研究中，经FOXO3工程改造的人胚胎干细胞衍生的血管细胞可改善血管内环境稳定并延缓血管衰老。本综述的目的是探讨FOXO3如何调节血管衰老及其在与衰老相关的血管疾病中的关键作用。
