Khandan Mohanna, Khazeei Tabari Mohammad Amin, Rahimi Seyed Mostafa, Hassani Mahmoud, Bagheri Abouzar
Mazandaran University of Medical Sciences, Sari, Iran.
Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 28. doi: 10.1007/s00210-025-04078-y.
Baicalein from Scutellaria baicalensis influences miRNA expression in various cancers, affecting key signaling pathways (PI3K/AKT, Wnt/β-catenin, mTOR) and processes like tumor growth, apoptosis, and metastasis. miRNAs, as small non-coding RNAs, play crucial roles in the cancer pathogenesis-associated gene regulations. This study is aimed at systematically reviewing the effects of baicalein on miRNA expression in various cancers. A comprehensive systematic review was conducted following PRISMA guidelines to investigate the impact of baicalein on miRNA expression in cancer. Databases including PubMed, Scopus, and Web of Science were systematically searched using key search terms. Inclusion criteria encompassed studies reporting changes in miRNA expression following baicalein treatment in cancer cell lines and animal models. Data extraction and risk of bias assessment based on SYRCLE's risk of bias tool were performed to ensure methodological rigor and reliability of the findings. Fifteen studies meeting the inclusion criteria were included in the systematic review. Baicalein impacts miRNA expression in cancers like hepatocellular carcinoma, breast, cervical, ovarian, and gastric cancers, suggesting its potential as a multi-cancer therapeutic. Baicalein regulates tumor-related genes (HDAC10, MDM2, Bcl-2/Bax, and Cyclin E1) and signaling molecules (AKT, FOXO3α), affecting cell viability, apoptosis, and cell cycle, indicating targeted therapeutic potential. In vitro and in vivo studies show baicalein inhibits tumor growth, enhances apoptosis, and regulates cell proliferation, supporting its anticancer effects. Baicalein exhibits potential in modulating miRNA expression in cancer, offering avenues for therapeutic intervention. However, methodological rigor in future studies is essential to enhance the reliability and validity of findings. Comprehensive understanding of baicalein's effects on miRNA expression holds promise for developing novel cancer treatment strategies.
黄芩中的黄芩素会影响多种癌症中的miRNA表达，影响关键信号通路（PI3K/AKT、Wnt/β-连环蛋白、mTOR）以及肿瘤生长、凋亡和转移等过程。miRNA作为小的非编码RNA，在癌症发病机制相关的基因调控中发挥着关键作用。本研究旨在系统评价黄芩素对多种癌症中miRNA表达的影响。按照PRISMA指南进行了全面的系统评价，以研究黄芩素对癌症中miRNA表达的影响。使用关键检索词对包括PubMed、Scopus和Web of Science在内的数据库进行了系统检索。纳入标准包括报告黄芩素处理癌细胞系和动物模型后miRNA表达变化的研究。基于SYRCLE偏倚风险工具进行数据提取和偏倚风险评估，以确保研究方法的严谨性和结果的可靠性。15项符合纳入标准的研究被纳入系统评价。黄芩素会影响肝细胞癌、乳腺癌、宫颈癌、卵巢癌和胃癌等癌症中的miRNA表达，表明其具有作为多种癌症治疗药物的潜力。黄芩素调节肿瘤相关基因（HDAC10、MDM2、Bcl-2/Bax和细胞周期蛋白E1）和信号分子（AKT、FOXO3α），影响细胞活力、凋亡和细胞周期，显示出靶向治疗潜力。体外和体内研究表明黄芩素可抑制肿瘤生长、增强凋亡并调节细胞增殖，支持其抗癌作用。黄芩素在调节癌症中miRNA表达方面具有潜力，为治疗干预提供了途径。然而，未来研究的方法严谨性对于提高结果的可靠性和有效性至关重要。全面了解黄芩素对miRNA表达的影响有望开发新的癌症治疗策略。
