人口统计学因素对帕金森病疲劳与生活质量关系的影响
Demographic Influences on the Relationship Between Fatigue and Quality of Life in Parkinson's Disease.
作者信息
Mantri Sneha, Chahine Lana M, Nabieva Karina, Feldman Robert, Althouse Andrew, Torsney Benjamin, Albert Steven M, Kopil Catherine, Marras Connie
机构信息
Department of Neurology Duke University School of Medicine Durham North Carolina USA.
Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.
出版信息
Mov Disord Clin Pract. 2021 Oct 28;9(1):76-81. doi: 10.1002/mdc3.13360. eCollection 2022 Jan.
BACKGROUND
Fatigue has a major impact on health-related quality of life (HR-QOL) in Parkinson's disease (PD).
OBJECTIVES
To determine whether demographic characteristics modify the relationship between fatigue and HR-QOL.
METHODS
Patients with PD in the Fox Insight study completed the Parkinson Fatigue Scale (PFS-16) and Geriatric Depression Scale (GDS-15). Linear regression examined the relationship between the PFS-16 and Parkinson Disease Quality of Life, as modified by age, sex, and GDS-15.
RESULTS
A total of 1029 participants (44% female, mean age 67.4 years, and mean disease duration 4.6 years) were included in this analysis. Multivariable regression modeling demonstrated a negative effect modification for age (β = -0.07, < 0.001) and a positive effect modification for the GDS-15 (β = 0.057, = 0.002), but not for sex (β = -0.021, = 0.231).
CONCLUSION
The association between fatigue and worse HR-QOL is greater at younger ages and in individuals with more depressive symptoms. Targeted therapeutics for these individuals may provide the greatest impact on fatigue in PD.
背景
疲劳对帕金森病（PD）患者与健康相关的生活质量（HR-QOL）有重大影响。
目的
确定人口统计学特征是否会改变疲劳与HR-QOL之间的关系。
方法
参加Fox Insight研究的PD患者完成了帕金森疲劳量表（PFS-16）和老年抑郁量表（GDS-15）。线性回归分析了PFS-16与帕金森病生活质量之间的关系，并根据年龄、性别和GDS-15进行了修正。
结果
本分析共纳入1029名参与者（44%为女性，平均年龄67.4岁，平均病程4.6年）。多变量回归模型显示年龄有负向效应修正（β = -0.07，< 0.001），GDS-15有正向效应修正（β = 0.057，= 0.002），但性别无效应修正（β = -0.021，= 0.231）。
结论
疲劳与较差的HR-QOL之间的关联在较年轻的年龄以及有更多抑郁症状的个体中更为明显。针对这些个体的靶向治疗可能对PD患者的疲劳产生最大影响。
Zotero 插件