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SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine.

作者信息

Huang Xia, Chen Qiuman, Luo Wenping, Pakvasa Mikhail, Zhang Yuxin, Zheng Liwen, Li Shuang, Yang Zhuohui, Zeng Huan, Liang Fang, Zhang Fugui, Hu Daniel A, Qin Kevin H, Wang Eric J, Qin David S, Reid Russell R, He Tong-Chuan, Athiviraham Aravind, El Dafrawy Mostafa, Zhang Hongmei

机构信息

Stomatological Hospital of Chongqing Medical University, Chongqing 401147, PR China.

Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, PR China.

出版信息

Genes Dis. 2020 Oct 17;9(1):95-107. doi: 10.1016/j.gendis.2020.10.003. eCollection 2022 Jan.

DOI:10.1016/j.gendis.2020.10.003
PMID:35005110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8720659/
Abstract

SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator, SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific, and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells, SATB2 plays a significant role in craniofacial pattern and skeleton development. In addition to regulating osteogenic differentiation, SATB2 also displays versatile functions in neural development and cancer progression. As an osteoinductive factor, SATB2 holds great promise in improving bone regeneration toward bone defect repair. In this review, we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development, neurogenesis, tumorigenesis and regenerative medicine.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d003/8720659/89d344c86cfb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d003/8720659/37a64bd69222/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d003/8720659/418819c0f394/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d003/8720659/89d344c86cfb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d003/8720659/37a64bd69222/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d003/8720659/418819c0f394/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d003/8720659/89d344c86cfb/gr3.jpg

相似文献

[1]
SATB2: A versatile transcriptional regulator of craniofacial and skeleton development, neurogenesis and tumorigenesis, and its applications in regenerative medicine.

Genes Dis. 2020-10-17

[2]
Role of Special AT-Rich Sequence-Binding Protein 2 in the Osteogenesis of Human Dental Mesenchymal Stem Cells.

Stem Cells Dev. 2020-8

[3]
Roles of SATB2 in osteogenic differentiation and bone regeneration.

Tissue Eng Part A. 2011-4-21

[4]
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.

Cell. 2006-6-2

[5]
Roles of SATB2 in site-specific stemness, autophagy and senescence of bone marrow mesenchymal stem cells.

J Cell Physiol. 2015-3

[6]
Lentiviral-mediated expression of SATB2 promotes osteogenic differentiation of bone marrow stromal cells in vitro and in vivo.

Eur J Oral Sci. 2014-6

[7]
The role of SATB2 in skeletogenesis and human disease.

Cytokine Growth Factor Rev. 2013-12-25

[8]
Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones.

Cell Tissue Res. 2012-9-7

[9]
Epigenetically Modified Bone Marrow Stromal Cells in Silk Scaffolds Promote Craniofacial Bone Repair and Wound Healing.

Tissue Eng Part A. 2015-8

[10]
[Study progress of special AT-rich sequence binding protein 2].

Yi Chuan. 2011-9

引用本文的文献

[1]
SATB2 promotes humeral fracture healing in rats by activating the PI3K/AKT pathway.

Open Life Sci. 2025-8-8

[2]
Influence of Polymorphisms in Gene SATB2 on Antipsychotics Response in Chinese Han Population.

Neuropsychiatr Dis Treat. 2025-7-25

[3]
Advances in research on SATB2 and its role in tumor development.

Cell Biosci. 2025-7-28

[4]
Beyond natural silk: Bioengineered silk fibroin for bone regeneration.

Mater Today Bio. 2025-6-23

[5]
Brain miR-137 governs growth and development via GH/IGF-1 signaling.

BMC Biol. 2025-7-1

[6]
Astragaloside IV inhibits nasopharyngeal carcinoma progression by suppressing the SATB2/Wnt signaling axis.

Toxicol Res (Camb). 2025-4-2

[7]
SATB2 promotes radiation resistance of esophageal squamous cell carcinoma by regulating epithelial-to-mesenchymal transition via the Wnt/β-catenin pathway.

Front Oncol. 2025-2-26

[8]
Reduced Expression of SATB2 in Colorectal Cancer and Its Association with Demographic and Clinicopathological Parameters.

Int J Mol Sci. 2025-3-6

[9]
CDX2 and SATB2 loss are associated with myeloid cell infiltration and poor survival in colorectal cancer.

Cancer Immunol Immunother. 2025-2-25

[10]
Molecular Regulation of Palatogenesis and Clefting: An Integrative Analysis of Genetic, Epigenetic Networks, and Environmental Interactions.

Int J Mol Sci. 2025-2-6

本文引用的文献

[1]
Higher expression of SATB2 in hepatocellular carcinoma of African Americans determines more aggressive phenotypes than those of Caucasian Americans.

J Cell Mol Med. 2019-10-11

[2]
LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2.

Mol Cancer. 2019-9-6

[3]
RUNX transcription factors: orchestrators of development.

Development. 2019-9-5

[4]
The biogenesis, biology and characterization of circular RNAs.

Nat Rev Genet. 2019-8-8

[5]
MicroRNA-449b-5p promotes the progression of osteoporosis by inhibiting osteogenic differentiation of BMSCs via targeting Satb2.

Eur Rev Med Pharmacol Sci. 2019-8

[6]
Satb2 expression in Foxc1-promoted osteogenic differentiation of MC3T3-E1 cells is negatively regulated by microRNA-103-3p.

Acta Biochim Biophys Sin (Shanghai). 2019-6-20

[7]
SatB2-Expressing Neurons in the Parabrachial Nucleus Encode Sweet Taste.

Cell Rep. 2019-5-7

[8]
Mutation update for the SATB2 gene.

Hum Mutat. 2019-6-18

[9]
A COEUR cohort study of SATB2 expression and its prognostic value in ovarian endometrioid carcinoma.

J Pathol Clin Res. 2019-4-20

[10]
Suppresses Colorectal Carcinoma Aggressiveness by Inhibiting SATB2-Dependent Transcription and Epithelial-Mesenchymal Transition.

Cancer Res. 2019-3-11

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