Huang Xia, Chen Qiuman, Luo Wenping, Pakvasa Mikhail, Zhang Yuxin, Zheng Liwen, Li Shuang, Yang Zhuohui, Zeng Huan, Liang Fang, Zhang Fugui, Hu Daniel A, Qin Kevin H, Wang Eric J, Qin David S, Reid Russell R, He Tong-Chuan, Athiviraham Aravind, El Dafrawy Mostafa, Zhang Hongmei
Stomatological Hospital of Chongqing Medical University, Chongqing 401147, PR China.
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, PR China.
Genes Dis. 2020 Oct 17;9(1):95-107. doi: 10.1016/j.gendis.2020.10.003. eCollection 2022 Jan.
SATB2 (special AT-rich sequence-binding protein 2) is a member of the special AT-rich binding protein family. As a transcription regulator, SATB2 mainly integrates higher-order chromatin organization. SATB2 expression appears to be tissue- and stage-specific, and is governed by several cellular signaling molecules and mediators. Expressed in branchial arches and osteoblast-lineage cells, SATB2 plays a significant role in craniofacial pattern and skeleton development. In addition to regulating osteogenic differentiation, SATB2 also displays versatile functions in neural development and cancer progression. As an osteoinductive factor, SATB2 holds great promise in improving bone regeneration toward bone defect repair. In this review, we have summarized our current understanding of the physiological and pathological functions of SATB2 in craniofacial and skeleton development, neurogenesis, tumorigenesis and regenerative medicine.
SATB2（富含AT序列的特殊结合蛋白2）是富含AT特殊结合蛋白家族的成员。作为一种转录调节因子，SATB2主要整合高阶染色质组织。SATB2的表达似乎具有组织和阶段特异性，并受多种细胞信号分子和介质调控。SATB2在鳃弓和成骨细胞系细胞中表达，在颅面形态和骨骼发育中发挥重要作用。除了调节成骨分化外，SATB2在神经发育和癌症进展中也具有多种功能。作为一种骨诱导因子，SATB2在促进骨缺损修复的骨再生方面具有巨大潜力。在本综述中，我们总结了目前对SATB2在颅面和骨骼发育、神经发生、肿瘤发生及再生医学中的生理和病理功能的认识。
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