Lucien Janet N, Ortega Madison T, Shaw Natalie D
Pediatric Neuroendocrinology Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, NC 27709.
Curr Opin Endocr Metab Res. 2021 Apr;17:1-7. doi: 10.1016/j.coemr.2020.09.009. Epub 2020 Oct 9.
In the 1970's, Boyar and colleagues made the seminal observation that during the early stages of puberty, there is a sleep-specific augmentation of pulsatile luteinizing hormone (LH) secretion. Building on this tantalizing association between sleep and the re-awakening of the neuro-reproductive axis, a number of investigators have since mapped the dynamic relationship between sleep and reproductive hormones across the pubertal transition. In this review, we focus on the complex, reciprocal relationship between sleep and reproductive hormones during adolescence as well as the potential effects of melatonin and orexin on gonadotropin-releasing hormone (GnRH) activity in children with chronic insomnia and narcolepsy, respectively. Given the important interaction between the reproductive and somatotropic axes during puberty, we end with a discussion of sleep and growth hormone (GH) secretion in children.
20世纪70年代，博亚尔及其同事做出了具有开创性的观察，即在青春期早期，促黄体生成素（LH）分泌存在特定于睡眠的脉冲式增加。基于睡眠与神经生殖轴重新激活之间这种诱人的关联，此后许多研究人员描绘了青春期过渡期间睡眠与生殖激素之间的动态关系。在这篇综述中，我们重点关注青春期睡眠与生殖激素之间复杂的相互关系，以及褪黑素和食欲素分别对慢性失眠儿童和发作性睡病儿童促性腺激素释放激素（GnRH）活性的潜在影响。鉴于青春期生殖轴与生长轴之间存在重要相互作用，我们最后讨论了儿童睡眠与生长激素（GH）分泌的问题。
