Haas Mark, Mirocha James, Amann Kerstin, Bajema Ingeborg M, Barisoni Laura, Becker Jan Ulrich, Jennette J Charles, Joh Kenuske, Ljubanovic Danica Galesic, Roberts Ian S D, Roelofs Joris J, Sethi Sanjeev, Suarez Raul, Zeng Caihong, Seshan Surya V
Department of Pathology & Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Clinical and Translational Science Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kidney Int Rep. 2021 Oct 29;7(1):78-86. doi: 10.1016/j.ekir.2021.10.014. eCollection 2022 Jan.
In 2020, a working group of 13 renal pathologists published consensus definitions for 47 individual glomerular lesions found on light microscopy (LM) and 47 glomerular lesions and 9 normal structures found on electron microscopy (EM).
To test the impact of these definitions on identification of these lesions and structures, 2 surveys were circulated to all members of the Renal Pathology Society (RPS), each having 32 images (19 LM, 13 EM) and accompanying questions with 5 multiple-choice answers, one being the consensus choice of the working group. The first survey (survey 1 [S1]), answered by 297 RPS members, was sent in September 2020, before publication of the consensus definitions. The second (survey 2 [S2]), with images of the same lesions and structures (but not the same images) and the same questions and multiple choices in different order, was sent in April 2020, 5 months after the publication of the definitions.
S2 was taken by 181 RPS members; 64% also took S1 and 61% reported having read the definitions paper (def. paper). Mean agreement with the consensus answers increased modestly between the 2 surveys (65.2% vs. 72.0%, = 0.097); the increase was greater and significant when only respondents to S2 who read the def. paper were considered (65.2% vs. 74.8%, = 0.026). Furthermore, in S2 agreement with consensus answers was greater among respondents who read this paper versus those who did not (66.9% vs. 74.8%, < 0.0001).
Publication of the consensus definitions modestly improved interobserver agreement in identification of glomerular lesions.
2020年，一个由13名肾脏病理学家组成的工作组发布了关于在光学显微镜（LM）下发现的47种个体肾小球病变以及在电子显微镜（EM）下发现的47种肾小球病变和9种正常结构的共识定义。
为测试这些定义对这些病变和结构识别的影响，向肾脏病理学会（RPS）的所有成员发放了2份调查问卷，每份问卷有32张图像（19张LM图像，13张EM图像）以及附带问题，有5个多项选择题答案，其中一个是工作组的共识选择。第一次调查（调查1 [S1]）由297名RPS成员回答，于2020年9月在共识定义发布前发送。第二次调查（调查2 [S2]），包含相同病变和结构的图像（但不是相同图像）以及相同问题和不同顺序的多项选择题，于2020年4月在定义发布5个月后发送。
181名RPS成员参与了S2；64%的成员也参与了S1，61%的成员报告阅读了定义文件（def. paper）。两次调查之间与共识答案的平均一致性略有提高（65.2%对72.0%， = 0.097）；当仅考虑阅读了def. paper的S2受访者时，提高幅度更大且具有统计学意义（65.2%对74.8%， = 0.026）。此外，在S2中，阅读该文件的受访者与未阅读的受访者相比，与共识答案的一致性更高（66.9%对74.8%， < 0.0001）。
共识定义的发布在肾小球病变识别方面适度提高了观察者间的一致性。
