Louw W K, Dormehl I C, Hugo N, Redelinghuys I F
Atomic Energy Corporation of South Africa Limited, Pretoria.
Eur J Nucl Med. 1993 Feb;20(2):96-100. doi: 10.1007/BF00168867.
Technetium-99m-labelled immunoglobulin G (99mTc-IgG) is a convenient and useful radio-pharmaceutical for the scintigraphic detection of inflammatory foci. However, unfavourable physiological biodistribution patterns such as high activities in the liver and especially in the kidneys impede the efficacy of this agent. This report describes biodistribution studies in the baboon model of various thiol reduction-mediated 99mTc-labelled immunoglobulins, including human IgG preparations (Sandoglobulin and Sigma: gamma-globulins prepared from Cohn fractions II and III) as well as baboon IgG preparations (Sigma: gamma-globulins prepared from Cohn fractions II and III and IgG isolated from the serum obtained from specific animals). The biodistribution studies demonstrated differences in kidney concentration, i.e. human IgG (Sandoglobulin) > baboon IgG (cross-over animal experiments with IgG isolated from the serum of the different animals) > human IgG (Sigma) approximately baboon IgG (Sigma) approximately baboon IgG (own IgG isolated from the serum of a specific animal, labelled with 99mTc and reinjected). Differences in liver concentration were also observed: human IgG (Sandoglobulin) < human IgG (Sigma) approximately baboon IgG (Sigma) approximately baboon IgG (own IgG) approximately IgG (cross-over). Characteristic were the relatively high activities in the liver and kidneys compared to those in other organs with high blood supply, and a relatively high retention in the blood pool.(ABSTRACT TRUNCATED AT 250 WORDS)
锝-99m标记的免疫球蛋白G（99mTc-IgG）是一种用于闪烁扫描检测炎症病灶的便捷且有用的放射性药物。然而，诸如肝脏尤其是肾脏中活性较高等不利的生理生物分布模式会妨碍该药物的疗效。本报告描述了在狒狒模型中对各种硫醇还原介导的99mTc标记免疫球蛋白的生物分布研究，包括人IgG制剂（桑多球蛋白和西格玛：由科恩II和III组分制备的γ球蛋白）以及狒狒IgG制剂（西格玛：由科恩II和III组分制备的γ球蛋白以及从特定动物血清中分离的IgG）。生物分布研究表明肾脏浓度存在差异，即人IgG（桑多球蛋白）＞狒狒IgG（用从不同动物血清中分离的IgG进行交叉动物实验）＞人IgG（西格玛）≈狒狒IgG（西格玛）≈狒狒IgG（从特定动物血清中分离的自身IgG，用99mTc标记后重新注射）。肝脏浓度也观察到差异：人IgG（桑多球蛋白）＜人IgG（西格玛）≈狒狒IgG（西格玛）≈狒狒IgG（自身IgG）≈IgG（交叉）。其特点是与其他高血供器官相比，肝脏和肾脏中的活性相对较高，并且在血池中保留相对较高。（摘要截断于250字）
