显微切割睾丸取精术后6年，不育睾丸发生睾丸精原细胞瘤。
Testicular seminoma arising from infertile testes 6 years after microdissection testicular sperm extraction.
作者信息
Shimizu Nobuhiko, Naiki Taku, Kobayashi Daichi, Naiki-Ito Aya, Kawai Tatsuya, Xiaochen Kuang, Etani Toshiki, Nozaki Satoshi, Tomiyama Nami, Aoki Maria, Matsuyama Nayuka, Iwatsuki Shoichiro, Umemoto Yukihiro, Yasui Takahiro
机构信息
Department of Nephro-urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan.
Department of Experimental Pathology and Tumor Biology Graduate School of Medical Sciences Nagoya City University Nagoya Japan.
出版信息
IJU Case Rep. 2021 Oct 27;5(1):53-56. doi: 10.1002/iju5.12391. eCollection 2022 Jan.
INTRODUCTION
In Western countries, the risk of a testicular germ cell tumor in men with male factor infertility is greater than in the general population. However, Japanese data on this risk are lacking. Additionally, the clinical course for the pathogenesis involved has not been clearly characterized.
CASE PRESENTATION
A 35-year-old Japanese male underwent a right orchiectomy because of a mass in his right scrotum. He had a previous history of microdissection testicular sperm extraction undertaken 6 years ago. The final diagnosis of the right scrotal mass was a stage I seminoma. However, a relapse occurred in the left inguinal lymph node 2 years after surgery and the patient was consequently treated with systemic chemotherapy. Pathological analysis of a microdissection testicular sperm extraction sample yielded a germ cell neoplasia in situ in the right testis.
CONCLUSION
In Japan, men who seek an evaluation for infertility might be more likely to develop testicular germ cell tumor.
引言
在西方国家，男性因素不育的男性患睾丸生殖细胞肿瘤的风险高于普通人群。然而，日本缺乏关于这种风险的数据。此外，所涉及的发病机制的临床过程尚未明确界定。
病例报告
一名35岁的日本男性因右侧阴囊肿物接受了右侧睾丸切除术。他曾在6年前接受过显微切割睾丸取精术。右侧阴囊肿物的最终诊断为I期精原细胞瘤。然而，术后2年左侧腹股沟淋巴结出现复发，因此患者接受了全身化疗。显微切割睾丸取精样本的病理分析显示右侧睾丸原位生殖细胞肿瘤形成。
结论
在日本，寻求不育评估的男性可能更易患睾丸生殖细胞肿瘤。
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