局部碳酸酐酶抑制剂对嗅觉的影响。
Effects of Topical Carbonic Anhydrase Inhibitors on the Olfactory Sense.
作者信息
Gul Fatih Cem, Guler Mete, Kobat Sabiha Gungor, Duzer Sertac, Sakallioglu Oner, Celik Fatih, Akyigit Abdulvahap
机构信息
Department of Ophthalmology, Health and Science University, Elazig Fethi Sekin City Hospital, Elazig, Turkey.
Department of Ophthalmology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.
出版信息
Beyoglu Eye J. 2021 Feb 13;6(1):19-23. doi: 10.14744/bej.2021.27676. eCollection 2021.
OBJECTIVES
The sense of smell plays an important role in daily life. Olfactory impairment can significantly affect an individual's quality of life. Topical carbonic anhydrase inhibitors are commonly used to treat elevated intraocular pressure (IOP). One potential side effect of these drugs is a loss of the sense of smell. This study is an examination of changes in olfactory function in patients who used dorzolamide and brinzolamide to control IOP after a laser capsulotomy.
METHODS
A total of 60 patients with posterior capsule opacification were included in the study. Sniffin' Sticks (Burghart Messtechnik GmbH, Wedel, Germany) were used to evaluate patient olfactory sensitivity before starting the topical treatment and after 1 week of treatment.
RESULTS
No statistically significant decrease in olfactory performance was observed in users of either brinzolamide or dorzolamide (p=0.705, p=0.405 respectively).
CONCLUSION
No negative effect on the sense of smell was determined after 7 days of topical application of a carbonic anhydrase enzyme inhibitor to the eye in patients with no previous anosmia.
目的
嗅觉在日常生活中起着重要作用。嗅觉障碍会显著影响个人生活质量。局部碳酸酐酶抑制剂常用于治疗眼压升高（IOP）。这些药物的一个潜在副作用是嗅觉丧失。本研究旨在检查在激光晶状体囊切开术后使用多佐胺和布林佐胺控制眼压的患者嗅觉功能的变化。
方法
本研究共纳入60例后囊膜混浊患者。在开始局部治疗前和治疗1周后，使用嗅觉棒（德国韦德尔的Burghart Messtechnik GmbH公司生产）评估患者的嗅觉敏感性。
结果
布林佐胺或多佐胺使用者的嗅觉表现均未观察到统计学上的显著下降（分别为p = 0.705，p = 0.405）。
结论
在既往无嗅觉丧失的患者中，眼部局部应用碳酸酐酶抑制剂7天后，未发现对嗅觉有负面影响。
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