Karakucuk Yalcin, Comez Aysegul, Beyoglu Abdullah, Yasa Dilek
Department of Ophthalmology, Selcuk University Faculty of Medicine, Konya, Turkey.
Department of Ophthalmology, Kahramanmaras Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey.
Beyoglu Eye J. 2021 Feb 16;6(1):43-48. doi: 10.14744/bej.2020.76588. eCollection 2021.
This study was designed to evaluate macular perfusion in a healthy pediatric population using optical coherence tomography angiography (OCTA).
Fifty-three eyes of 30 healthy children (20 boys and 10 girls) were included in this prospective, cross-sectional study. Age, gender, foveal thickness (FT), superficial foveal avascular zone area (FAZs), deep foveal avascular zone area (FAZd), superficial capillary plexus flow area (SCP), deep capillary plexus flow area (DCP), choriocapillaris flow area (CC), vascular density in the SCP (VDs), vascular density in the DCP (VDd), and subfoveal choroidal thickness (SFCT) were evaluated.
The mean age was 12.0±4.0 years (range: 6-15 years). Gender did not have a statistically significant influence on the FAZs or FAZd. However, there was a positive correlation between the CC and age (r=0.31; p=0.025). The FAZs and FAZd were negatively correlated with the FT (p<0.001). The VDd was positively correlated with the FT (p=0.03) and was negatively correlated with the FAZd (p=0.019).
The present study determined normative data of OCTA parameters in healthy children and provides useful insight into the relationship between age, macular microvascular networks, and the FAZ.
本研究旨在使用光学相干断层扫描血管造影（OCTA）评估健康儿童群体的黄斑灌注情况。
本前瞻性横断面研究纳入了30名健康儿童（20名男孩和10名女孩）的53只眼睛。评估了年龄、性别、中央凹厚度（FT）、浅表中央凹无血管区面积（FAZs）、深部中央凹无血管区面积（FAZd）、浅表毛细血管丛血流面积（SCP）、深部毛细血管丛血流面积（DCP）、脉络膜毛细血管血流面积（CC）、SCP中的血管密度（VDs）、DCP中的血管密度（VDd）以及黄斑下脉络膜厚度（SFCT）。
平均年龄为12.0±4.0岁（范围：6 - 15岁）。性别对FAZs或FAZd没有统计学上的显著影响。然而，CC与年龄之间存在正相关（r = 0.31；p = 0.025）。FAZs和FAZd与FT呈负相关（p < 0.001）。VDd与FT呈正相关（p = 0.03），与FAZd呈负相关（p = 0.019）。
本研究确定了健康儿童OCTA参数的规范数据，并为年龄、黄斑微血管网络和FAZ之间的关系提供了有用的见解。
