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注意力缺陷多动障碍与炎症：现有知识告诉了我们什么？一项系统综述。

Attention-Deficit/Hyperactivity Disorder And Inflammation: What Does Current Knowledge Tell Us? A Systematic Review.

作者信息

Anand Deepa, Colpo Gabriela D, Zeni Gregory, Zeni Cristian P, Teixeira Antonio L

机构信息

Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston - UT Health, Houston, TX, United States.

Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

出版信息

Front Psychiatry. 2017 Nov 9;8:228. doi: 10.3389/fpsyt.2017.00228. eCollection 2017.

DOI:10.3389/fpsyt.2017.00228
PMID:29170646
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5684106/
Abstract

BACKGROUND

Attention-deficit/hyperactivity disorder (ADHD) is a complex condition that interferes with development and/or functioning. Our objective is to investigate the potential association between ADHD and inflammation.

METHODS

We conducted a systematic review of human studies measuring inflammatory markers in ADHD. The studies were identified by searching PUBMED, MEDLINE, EMBASE, PSYCHINFO, COCHRANE, and SCOPUS databases for peer-reviewed journals published until September 2016. We included cytokine gene expression and protein measured. Fourteen papers met the inclusion criteria.

RESULTS

Seven studies evaluated the association of cytokine gene polymorphisms in ADHD, and six studies measured cytokines levels in blood. One study analyzed the presence of cytokines in cerebrospinal fluid in patients with ADHD. Altogether, these studies indicate a possible role of inflammation in ADHD pathogenesis, despite the significant heterogeneity and contradictory results.

CONCLUSION

Evidence points to the association of ADHD with inflammatory processes, but more studies are warranted.

摘要

背景

注意力缺陷多动障碍（ADHD）是一种干扰发育和/或功能的复杂病症。我们的目的是研究ADHD与炎症之间的潜在关联。

方法

我们对测量ADHD炎症标志物的人体研究进行了系统综述。通过检索PUBMED、MEDLINE、EMBASE、PSYCHINFO、COCHRANE和SCOPUS数据库，查找截至2016年9月发表的同行评审期刊，从而确定这些研究。我们纳入了细胞因子基因表达和蛋白质测量。14篇论文符合纳入标准。

结果

7项研究评估了ADHD中细胞因子基因多态性的关联，6项研究测量了血液中的细胞因子水平。1项研究分析了ADHD患者脑脊液中细胞因子的存在情况。总体而言，尽管存在显著的异质性和相互矛盾的结果，但这些研究表明炎症在ADHD发病机制中可能起作用。

结论

有证据表明ADHD与炎症过程有关，但仍需要更多研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52da/5684106/d116d7dd09b3/fpsyt-08-00228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52da/5684106/d116d7dd09b3/fpsyt-08-00228-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52da/5684106/d116d7dd09b3/fpsyt-08-00228-g001.jpg

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3
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