Sun Yamin, Lin Wenchao, Dong Wei, Xu Jianguo
Research Institute of Public Health, Nankai University, Tianjin, PR China.
Engineering and Research Center for Microbial Functional Genomics and Detection Technology, Ministry of Education, Nankai University.
J Biosaf Biosecur. 2022 Jun;4(1):33-37. doi: 10.1016/j.jobb.2021.12.001. Epub 2021 Dec 31.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved rapidly into new variants throughout the pandemic. The Omicron variant has more than 50 mutations when compared with the original wild-type strain and has been identified globally in numerous countries. In this report, we analyzed the mutational profiles of several variants, including the per-site mutation rate, to determine evolutionary relationships. The Omicron variant was found to have a unique mutation profile when compared with that of other SARS-CoV-2 variants, containing mutations that are rare in clinical samples. Moreover, the presence of five mouse-adapted mutation sites suggests that Omicron may have evolved in a mouse host. Mutations in the Omicron receptor-binding domain (RBD) region, in particular, have potential implications for the ongoing pandemic.
在整个疫情大流行期间，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）迅速演变成新的变种。与原始野生型毒株相比，奥密克戎变种有50多个突变，并且已在全球多个国家被发现。在本报告中，我们分析了几种变种的突变特征，包括每个位点的突变率，以确定进化关系。与其他SARS-CoV-2变种相比，发现奥密克戎变种具有独特的突变特征，包含在临床样本中罕见的突变。此外，五个适应小鼠的突变位点的存在表明奥密克戎可能是在小鼠宿主中进化而来的。特别是，奥密克戎受体结合域（RBD）区域的突变对当前的疫情大流行具有潜在影响。
