Rathinasamy Muthusami, Kandhasamy Saritha
Department of Computer Applications, Dr. Mahalingam College of Engineering and Technology, Pollachi, Tamil Nadu, India.
Department of Mathematics, P. A. College of Engineering and Technology, Pollachi, Tamil Nadu, India.
J Med Virol. 2022 Jun;94(6):2414-2421. doi: 10.1002/jmv.27634. Epub 2022 Feb 26.
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolves, it accumulates mutations, which are changes in the genetic code. Because this virus has built-in RNA repair mechanisms, it generates mutations more slowly than some other RNA viruses. Thousands of mutations have emerged since the beginning of the pandemic throughout all virus genomes sequenced to date, resulting in thousands of distinct variants. However, some variants have recently been discovered that appear to increase transmissibility and may affect illness pervasiveness. In this study, we investigated SARS-CoV-2 variants and how countries intervene with them. We also depicted the top 25 countries where the Omicron variant is prevalent, with the UK, US, Denmark, France, and Australia having the top five places as of January 13, 2022. The perception of SARS-CoV-2 variants was investigated in those five countries, and the propagation rate of the Omicron variant was determined to be 51%, 29%, 26%, 15%, and 44%, respectively, indicating that the Omicron variant is the most prevalent among the others. Then, a study of SARS-CoV-2 infection test rate based on tests conducted per one million populations with a number of sequences in those five countries reveals that 25%, 73%, 1.6%, 4.8%, and 1.5%, respectively, it suggests that viral testing should be increased in all five countries since it will help to determine the precise distribution of variants and aid governments in making policy decisions for public safety. We anticipated the production of new variants strains. This study implies that limiting disease transmissions, such as acquiring a coronavirus disease 2019 vaccine and booster doses for those aged 18 and older, as well as wearing the mask in public places, is the best strategy to prevent the emergence of new variants.
随着严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的进化，它会积累突变，即遗传密码的改变。由于这种病毒具有内置的RNA修复机制，它产生突变的速度比其他一些RNA病毒要慢。自疫情开始以来，在所有已测序的病毒基因组中出现了数千种突变，产生了数千种不同的变体。然而，最近发现一些变体似乎增加了传播性，并可能影响疾病的普遍程度。在本研究中，我们调查了SARS-CoV-2变体以及各国如何对其进行干预。我们还描绘了奥密克戎变体流行的前25个国家，截至2022年1月13日，英国、美国、丹麦、法国和澳大利亚位列前五。我们在这五个国家调查了对SARS-CoV-2变体的认知情况，确定奥密克戎变体的传播率分别为51%、29%、26%、15%和44%，这表明奥密克戎变体在其他变体中最为流行。然后，根据这五个国家每百万人口进行的检测数量以及检测序列数量对SARS-CoV-2感染检测率进行的一项研究表明，其感染检测率分别为25%、73%、1.6%、4.8%和1.5%，这表明这五个国家都应增加病毒检测，因为这将有助于确定变体的精确分布，并协助政府做出公共安全政策决策。我们预计会产生新的变异毒株。这项研究表明，限制疾病传播，如为18岁及以上人群接种2019冠状病毒病疫苗和加强针，以及在公共场所佩戴口罩，是预防新变体出现的最佳策略。
