Biomedical Engineering Institute, School of Medicine, Université de Montréal, Montreal, Quebec H2X 0A9, Canada.
Department of Physics, Sharif University of Technology, P.O. Box 11155-9161, Tehran , Iran.
ACS Appl Bio Mater. 2021 Dec 20;4(12):8110-8128. doi: 10.1021/acsabm.1c00932. Epub 2021 Nov 29.
The design of advanced nanobiomaterials to improve analytical accuracy and therapeutic efficacy has become an important prerequisite for the development of innovative nanomedicines. Recently, phospholipid nanobiomaterials including 2-methacryloyloxyethyl phosphorylcholine (MPC) have attracted great attention with remarkable characteristics such as resistance to nonspecific protein adsorption and cell adhesion for various biomedical applications. Despite many recent reports, there is a lack of comprehensive review on the phospholipid nanobiomaterials from synthesis to diagnostic and therapeutic applications. Here, we review the synthesis and characterization of phospholipid nanobiomaterials focusing on MPC polymers and highlight their attractive potentials for applications in micro/nanofabricated fluidic devices, biosensors, lab-on-a-chip, drug delivery systems (DDSs), COVID-19 potential usages for early diagnosis and even treatment, and artificial extracellular matrix scaffolds for cellular engineering.
为了提高分析准确性和治疗效果，设计先进的纳米生物材料已成为开发创新型纳米药物的重要前提。最近，包括 2-（甲基丙烯酰氧）乙基磷酸胆碱（MPC）在内的磷脂纳米生物材料因其具有抵抗非特异性蛋白质吸附和细胞黏附等显著特性，而在各种生物医学应用中引起了极大关注。尽管最近有很多相关报道，但缺乏对从合成到诊断和治疗应用的磷脂纳米生物材料的全面综述。在这里，我们综述了磷脂纳米生物材料的合成和表征，重点介绍了 MPC 聚合物的特性，并强调了其在微纳流控装置、生物传感器、芯片实验室、药物传递系统（DDS）、COVID-19 的早期诊断甚至治疗以及用于细胞工程的人工细胞外基质支架等方面的应用潜力。
