Ishihara Kazuhiko
Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, Osaka, Japan.
Sci Technol Adv Mater. 2022 Sep 13;23(1):498-524. doi: 10.1080/14686996.2022.2119883. eCollection 2022.
This review summarizes recent research on the design of polymer material systems based on biomimetic concepts and reports on the medical devices that implement these systems. Biomolecules such as proteins, nucleic acids, and phospholipids, present in living organisms, play important roles in biological activities. These molecules are characterized by heterogenic nature with hydrophilicity and hydrophobicity, and a balance of positive and negative charges, which provide unique reaction fields, interfaces, and functionality. Incorporating these molecules into artificial systems is expected to advance material science considerably. This approach to material design is exceptionally practical for medical devices that are in contact with living organisms. Here, it is focused on zwitterionic polymers with intramolecularly balanced charges and introduce examples of their applications in medical devices. Their unique properties make these polymers potential surface modification materials to enhance the performance and safety of conventional medical devices. This review discusses these devices; moreover, new surface technologies have been summarized for developing human-friendly medical devices using zwitterionic polymers in the cardiovascular, cerebrovascular, orthopedic, and ophthalmology fields.
本综述总结了基于仿生概念的高分子材料系统设计的最新研究，并报告了应用这些系统的医疗器械。存在于生物体中的蛋白质、核酸和磷脂等生物分子在生物活动中发挥着重要作用。这些分子具有亲水性和疏水性的异质性质以及正负电荷的平衡，这提供了独特的反应场、界面和功能。将这些分子纳入人工系统有望极大地推动材料科学的发展。这种材料设计方法对于与生物体接触的医疗器械尤为实用。在此，重点关注分子内电荷平衡的两性离子聚合物，并介绍其在医疗器械中的应用实例。它们的独特性质使这些聚合物成为增强传统医疗器械性能和安全性的潜在表面改性材料。本综述讨论了这些器械；此外，还总结了利用两性离子聚合物在心血管、脑血管、骨科和眼科领域开发人性化医疗器械的新表面技术。
