Sánchez Ibarrola A, Valdivieso R, Wong E, Sánchez Arroyo R
Clinica Universitaria, Universidad de Navarra, Pamplona, Spain.
Allergol Immunopathol (Madr). 1987 Jul-Aug;15(4):195-200.
The subclass distribution of anti-ENA antibodies was investigated in the serum of patients with systemic rheumatic diseases, using an ELISA technique. All the sera studied were previously detected positive for anti-ENA antibodies by other technique (gel precipitation). The patients were classified according to the enzymatic sensitivity of the antigen against the antibodies. There was no subclass restriction for antibodies against Ribonuclease-sensitive ENA antigen or other ENA antigens. Progressive studies showed that a single pattern of subclass distribution for each serum was maintained.
采用酶联免疫吸附测定（ELISA）技术，对系统性风湿疾病患者血清中抗可提取性核抗原（ENA）抗体的亚类分布进行了研究。所有研究的血清之前通过其他技术（凝胶沉淀法）检测抗ENA抗体呈阳性。根据抗原对抗体的酶敏感性对患者进行分类。针对核糖核酸酶敏感的ENA抗原或其他ENA抗原的抗体不存在亚类限制。进一步研究表明，每份血清的亚类分布模式保持单一。
