Decouflé P, Walrath J
Division of Chronic Disease Control, Centers for Disease Control, Atlanta, GA 30333.
Am J Ind Med. 1987;12(5):605-13. doi: 10.1002/ajim.4700120513.
Studies in England and Italy have demonstrated a striking association between employment in the shoemaking industry and cancer of the nasal cavities and sinuses. However, three recent, large-scale proportionate mortality studies of U.S. shoeworkers do not show any deaths from these tumors. This paper reviews the methodology of those studies, emphasizing the underlying data and statistical power. In addition, epidemiologic and other considerations important in assessing and interpreting the apparent absence of a nasal cancer risk in the U.S. shoe industry are discussed.
英国和意大利的研究表明，制鞋行业的就业与鼻腔和鼻窦癌之间存在显著关联。然而，最近对美国制鞋工人进行的三项大规模比例死亡率研究并未显示出这些肿瘤导致的死亡情况。本文回顾了这些研究的方法，重点关注基础数据和统计效力。此外，还讨论了在评估和解释美国制鞋行业明显不存在鼻咽癌风险时重要的流行病学及其他考量因素。
