Department of Medical Devices, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-Ahmedabad), Gandhinagar, Gujarat 382355, India.
ACS Appl Bio Mater. 2021 Nov 15;4(11):7721-7737. doi: 10.1021/acsabm.1c00500. Epub 2021 Oct 15.
Translation of tissue engineering strategies for the regeneration of intervertebral disc (IVD) requires a strong understanding of pathophysiology through the relevant animal model. There is no relevant animal model due to differences in disc anatomy, cellular composition, extracellular matrix components, disc physiology, and mechanical strength from humans. However, available animal models if used correctly could provide clinically relevant information for the translation into humans. In this review, we have investigated different types of strategies for the development of clinically relevant animal models to study biomaterials, cells, biomolecular or their combination in developing tissue engineering-based treatment strategies. Tissue engineering strategies that utilize various animal models for IVD regeneration are summarized and outcomes have been discussed. The understanding of animal models for the validation of regenerative approaches is employed to understand and treat the pathophysiology of degenerative disc disease (DDD) before proceeding for human trials. These animal models play an important role in building a therapeutic regime for IVD tissue regeneration, which can serve as a platform for clinical applications.
组织工程策略在用于椎间盘（IVD）再生方面的翻译需要通过相关的动物模型深入了解病理生理学。由于解剖学、细胞组成、细胞外基质成分、椎间盘生理学和机械强度方面与人类存在差异，因此不存在相关的动物模型。但是，如果正确使用现有动物模型，它们可以为转化为人类提供临床相关信息。在这篇综述中，我们研究了不同类型的策略，以开发临床相关的动物模型，从而研究生物材料、细胞、生物分子或它们的组合，以开发基于组织工程的治疗策略。总结了利用各种动物模型进行 IVDR 的组织工程策略，并讨论了其结果。通过动物模型对再生方法进行验证的理解被用于在进行人体试验之前了解和治疗退行性椎间盘疾病（DDD）的病理生理学。这些动物模型在构建 IVDR 组织再生的治疗方案方面发挥着重要作用，可作为临床应用的平台。
