两亲性 DTPA 多聚体组装在笼状-硼烷结构上作为高性能 MRI 血池造影剂。
Amphiphilic DTPA Multimer Assembled on Icosahedral -Borane Motif as High-Performance MRI Blood Pool Contrast Agent.
机构信息
International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, Missouri 65212, United States.
Molecular and Cellular Imaging Laboratory, Department of Radiology, Michigan State University, East Lansing, Michigan 48823, United States.
出版信息
ACS Appl Bio Mater. 2021 Sep 20;4(9):6658-6663. doi: 10.1021/acsabm.1c00717. Epub 2021 Aug 25.
Abstract
A multimeric MRI blood pool contrast agent based on the -borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized -borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement and .
摘要
报道了一种基于 -硼烷结构的多聚体 MRI 血池对比剂。通过氨基甲酸酯键将 12 个带有胺端基的两亲性 DTPA 螯合物连接到碳酸酯功能化的 -硼烷结构上。修饰后的 DTPA 螯合物上的外围苯基基团使其具有高的人血清白蛋白结合率、高弛豫率和优异的对比增强效果。
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