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Buckyball-Based Spherical Display of Crown Ethers for Custom Design of Ion Transport Selectivity.基于巴基球的冠醚的球面展示用于定制离子传输选择性。
J Am Chem Soc. 2020 Dec 16;142(50):21082-21090. doi: 10.1021/jacs.0c09655. Epub 2020 Dec 4.
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Low-Field MRI of Stroke: Challenges and Opportunities.卒中的低场 MRI：挑战与机遇。
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Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis.用于转化纳米治疗的树枝状大分子：简明关键步骤分析
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Tuning the properties of atomically precise gold nanoclusters for biolabeling and drug delivery.调整原子精确金纳米团簇的性质，用于生物标记和药物传递。
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An Organometallic Strategy for Assembling Atomically Precise Hybrid Nanomaterials.一种用于组装原子精度的杂化纳米材料的有机金属策略。
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Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances.基于 Gd(III)的对比剂的分子磁共振成像：挑战与关键进展。
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A multimeric MRI contrast agent based on a closo-borane scaffold bearing modified AAZTA chelates on the periphery.一种基于笼型硼烷骨架的多聚体 MRI 对比剂，其外围带有修饰后的 AAZTA 螯合物。
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两亲性 DTPA 多聚体组装在笼状-硼烷结构上作为高性能 MRI 血池造影剂。

Amphiphilic DTPA Multimer Assembled on Icosahedral -Borane Motif as High-Performance MRI Blood Pool Contrast Agent.

机构信息

International Institute of Nano and Molecular Medicine and Department of Radiology, University of Missouri, Columbia, Missouri 65212, United States.

Molecular and Cellular Imaging Laboratory, Department of Radiology, Michigan State University, East Lansing, Michigan 48823, United States.

出版信息

ACS Appl Bio Mater. 2021 Sep 20;4(9):6658-6663. doi: 10.1021/acsabm.1c00717. Epub 2021 Aug 25.

DOI:10.1021/acsabm.1c00717
PMID:35006969
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8793076/
Abstract

A multimeric MRI blood pool contrast agent based on the -borane motif is reported. Twelve copies of an amphiphilic DTPA chelate with amine end groups are appended on carbonate-functionalized -borane motif using carbamate linkages. The presence of peripheral phenyl groups on the modified DTPA chelates results in high human serum albumin binding, high relaxivity, and excellent contrast enhancement and .

摘要

报道了一种基于 -硼烷结构的多聚体 MRI 血池对比剂。通过氨基甲酸酯键将 12 个带有胺端基的两亲性 DTPA 螯合物连接到碳酸酯功能化的 -硼烷结构上。修饰后的 DTPA 螯合物上的外围苯基基团使其具有高的人血清白蛋白结合率、高弛豫率和优异的对比增强效果。