Martin V V, Ralston W H, Hynes M R, Keana J F
Department of Chemistry, University of Oregon, Eugene 97403, USA.
Bioconjug Chem. 1995 Sep-Oct;6(5):616-23. doi: 10.1021/bc00035a017.
A new series of gadolinium chelates designed as blood pool contrast enhancing agents for magnetic resonance imaging applications is described. Complexes having four Gd(III) chelate units display a significant increase in molecular relaxivity per gadolinium ion in water (9-13 L x mmol(-1) x (s-1) compared to Gd(III)-DTPA (5 L x mmol(-1) x s(-1). A further jump in relaxivity (25 L x mmol(-1) x sec(-1) in 4% BSA solution was observed in the case of a fatty acid-containing tetrachelate and is attributed to noncovalent binding of the tetrachelate to serum albumin. This agent was successfully used for imaging the rat circulatory system.
本文描述了一系列新的钆螯合物，它们被设计用作磁共振成像应用中的血池造影剂。具有四个钆（III）螯合单元的配合物在水中每个钆离子的分子弛豫率显著增加（9 - 13 L·mmol⁻¹·s⁻¹），相比之下钆（III）-二乙三胺五乙酸（Gd(III)-DTPA）为5 L·mmol⁻¹·s⁻¹。在含脂肪酸的四螯合物的情况下，在4%牛血清白蛋白溶液中弛豫率进一步跃升（25 L·mmol⁻¹·sec⁻¹），这归因于四螯合物与血清白蛋白的非共价结合。该造影剂已成功用于大鼠循环系统成像。
