Imaging Department, The Third Hospital of Shanxi Medical University, Taiyuan 030032, China.
Shanxi Medical University, Taiyuan 030001, China.
ACS Appl Bio Mater. 2021 Jun 21;4(6):5312-5323. doi: 10.1021/acsabm.1c00423. Epub 2021 Jun 3.
Laryngeal cancer is highly aggressive and insensitive to conventional targeted therapies, which often result in poor therapeutic outcomes. Image-guided precision therapy is a promising strategy in oncology that has superior safety and efficacy versus conventional therapies. Here, we present a multifunctional theranostic nanoplatform based on melanin-coated gold nanorod (GNR) that exhibits excellent multimodal imaging ability and photothermal effects. These attributes make the platform applicable for multimodal photoacoustic (PA)/positron emission tomography (PET)/magnetic resonance (MR) image-guided photothermal treatment of laryngeal cancer. The melanin nanoparticles markedly suppress the cytotoxicity of the template cetyltrimethylammonium bromide bilayer and conferred the GNR with excellent PET/MR imaging performances, due to their native biocompatibilities and strong affinities to metal ions. Moreover, the introduction of GNR to the melanin nanoparticles greatly improved the near-infrared absorbances and passive targeting capabilities, leading to exceptional PA imaging and photothermal ablation of tumors. The nanoplatform exhibits high stability and dispersity under physiological conditions. After intravenous injection, the nanoplatform could be precisely tracked and enabled laryngopharyngeal superficial cancer to be located and imaged. Combined photothermal therapy effectively ablated tumors with negligible side effects. Thus, this work presents a unique and biocompatible nanoplatform that allows multimodal imaging, high anti-tumor PTT efficacy, and negligible side effects in the treatment of laryngeal cancer.
喉癌具有高度侵袭性，对传统的靶向治疗不敏感，这往往导致治疗效果不佳。图像引导的精准治疗是肿瘤学中一种很有前途的策略，与传统治疗相比，它具有更高的安全性和疗效。在这里，我们提出了一种基于黑色素包覆的金纳米棒（GNR）的多功能诊疗纳米平台，该平台具有优异的多模态成像能力和光热效应。这些特性使得该平台适用于多模态光声（PA）/正电子发射断层扫描（PET）/磁共振（MR）成像引导的喉癌光热治疗。由于黑色素纳米粒子具有天然的生物相容性和对金属离子的强烈亲和力，因此显著抑制了模板十六烷基三甲基溴化铵双层的细胞毒性，并赋予了 GNR 优异的 PET/MR 成像性能。此外，GNR 的引入极大地提高了近红外吸收和被动靶向能力，导致肿瘤的 PA 成像和光热消融效果异常出色。该纳米平台在生理条件下具有高稳定性和分散性。静脉注射后，该纳米平台可以被精确追踪，并能够定位和成像喉咽浅表癌。联合光热疗法有效地消融了肿瘤，几乎没有副作用。因此，这项工作提出了一种独特的、具有生物相容性的纳米平台，允许进行多模态成像、高效的抗肿瘤 PTT 治疗，并且在治疗喉癌方面几乎没有副作用。
