Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.
Org Lett. 2022 Jan 21;24(2):762-766. doi: 10.1021/acs.orglett.1c04266. Epub 2022 Jan 10.
Enantioselective Cu-catalyzed C-O cross coupling reactions yielding atropisomeric resorcinol-bearing quinazolinones have been developed. Utilizing a new guanidinylated dimeric peptidic ligand, a set of products were generated in good yields with excellent stereocontrol. The transformation was readily scalable, and a range of product derivatizations were performed.
已开发出对映选择性铜催化 C-O 交叉偶联反应,生成具有阻转异构的间苯二酚取代的喹唑啉酮。利用一种新的胍基化二聚肽配体,以良好的收率和优异的立体选择性生成了一组产物。该转化易于规模化,并进行了一系列产物衍生化。