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表皮生长因子与胰高血糖素一样，对大鼠肝细胞中的丙氨酸转运具有短期刺激作用。

Epidermal growth factor, like glucagon, exerts a short-term stimulation of alanine transport in rat hepatocytes.

作者信息

Moule S K, McGivan J D

机构信息

Department of Biochemistry, University of Bristol Medical School, U.K.

出版信息

Biochem J. 1987 Oct 1;247(1):233-5. doi: 10.1042/bj2470233.

DOI:10.1042/bj2470233
PMID:3500715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1148393/
Abstract

Epidermal growth factor causes a transient stimulation of alanine transport in hepatocytes. The stimulation is maximal after 30 min, and the rate returns to the control value after 90 min. These characteristics are very similar to the short-term stimulation of alanine transport by glucagon, which has been attributed to cell membrane hyperpolarization.

摘要

表皮生长因子可引起肝细胞中丙氨酸转运的短暂刺激。这种刺激在30分钟后达到最大值，90分钟后速率恢复到对照值。这些特征与胰高血糖素对丙氨酸转运的短期刺激非常相似，后者被认为是由于细胞膜超极化所致。

相似文献

1
Epidermal growth factor, like glucagon, exerts a short-term stimulation of alanine transport in rat hepatocytes.表皮生长因子与胰高血糖素一样，对大鼠肝细胞中的丙氨酸转运具有短期刺激作用。
Biochem J. 1987 Oct 1;247(1):233-5. doi: 10.1042/bj2470233.
2
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3
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本文引用的文献

1
Biphasic stimulation of amino acid uptake by glucagon in hepatocytes.胰高血糖素对肝细胞氨基酸摄取的双相刺激作用。
Biochem Biophys Res Commun. 1980 Sep 16;96(1):61-8. doi: 10.1016/0006-291x(80)91181-x.
2
Plasma-membrane transport of alanine is rate-limiting for its metabolism in rat-liver parenchymal cells.丙氨酸在大鼠肝脏实质细胞中的代谢，其质膜转运是限速步骤。
FEBS Lett. 1980 Oct 6;119(2):271-4. doi: 10.1016/0014-5793(80)80269-9.
3
Membrane potential measurements during rat liver regeneration.大鼠肝脏再生过程中的膜电位测量
J Cell Physiol. 1980 Feb;102(2):193-7. doi: 10.1002/jcp.1041020210.
4
Stimulation of alanine transport and metabolism by dibutyryl cyclic AMP in the hepatocytes from fed rats. Assessment of transport as a potential rate-limiting step for alanine metabolism.二丁酰环磷腺苷对饱食大鼠肝细胞丙氨酸转运和代谢的刺激作用。将转运评估为丙氨酸代谢的潜在限速步骤。
Biochim Biophys Acta. 1981 Jun 22;644(2):295-304. doi: 10.1016/0005-2736(81)90387-4.
5
Epidermal growth factor stimulates monovalent cation transport in isolated rat hepatocytes.
Biochem Biophys Res Commun. 1981 May 15;100(1):254-60. doi: 10.1016/s0006-291x(81)80090-3.
6
EGF inhibits glucagon stimulation of amino acid transport in primary cultures of adult rat hepatocytes.表皮生长因子抑制成年大鼠肝细胞原代培养物中胰高血糖素对氨基酸转运的刺激作用。
FEBS Lett. 1981 May 5;127(1):109-11. doi: 10.1016/0014-5793(81)80353-5.
7
Stimulation of Rb+ transport by glucagon in isolated rat hepatocytes.
J Biol Chem. 1981 Mar 10;256(5):2213-8.
8
Effects of growth factors on hormonal stimulation of amino acid transport in primary cultures of rat hepatocytes.生长因子对原代培养大鼠肝细胞中激素刺激氨基酸转运的影响。
Biochem J. 1983 Feb 15;210(2):361-6. doi: 10.1042/bj2100361.
9
Mechanism of the inhibitory effect of EGF on cAMP-stimulated amino acid transport.表皮生长因子对环磷酸腺苷刺激的氨基酸转运的抑制作用机制
Mol Cell Endocrinol. 1984 Aug;37(1):103-7. doi: 10.1016/0303-7207(84)90132-1.
10
Epidermal growth factor. Characteristics of specific binding in membranes from liver, placenta, and other target tissues.表皮生长因子。肝脏、胎盘及其他靶组织膜中特异性结合的特性。
Arch Biochem Biophys. 1974 Oct;164(2):518-26. doi: 10.1016/0003-9861(74)90062-9.