Uribe-Gomez Juan, Schönfeld Dennis, Posada-Murcia Andrés, Roland Michel-Manuel, Caspari Anja, Synytska Alla, Salehi Sahar, Pretsch Thorsten, Ionov Leonid
Faculty of Engineering Sciences and Bavarian Polymer Institute, University of Bayreuth, Ludwig Thoma Str. 36A, Bayreuth, 95447, Germany.
Fraunhofer Institute for Applied Polymer Research IAP, Geiselbergstr. 69, Potsdam, 14476, Germany.
Macromol Biosci. 2022 Apr;22(4):e2100427. doi: 10.1002/mabi.202100427. Epub 2022 Jan 17.
Development of fiber-spinning technologies and materials with proper mechanical properties is highly important for the manufacturing of aligned fibrous scaffolds mimicking structure of the muscle tissues. Here, the authors report touch spinning of a thermoplastic poly(1,4-butylene adipate)-based polyurethane elastomer, obtained via solvent-free polymerization. This polymer possesses a combination of important advantages such as 1) low elastic modulus in the range of a few MPa, 2) good recovery ratio and 3) resilience, 4) processability, 5) nontoxicity, 6) biocompatibility, and 7) biodegradability that makes it suitable for fabrication of structures mimicking extracellular matrix of muscle tissue. Touch spinning allows fast and precise deposition of highly aligned micro- and nano-fibers without use of high voltage. C2C12 myoblasts readily align along soft polymer fibers and demonstrate high viability as well as proliferation that make proposed combination of polymer and fabrication method highly suitable for engineering skeletal muscles.
开发具有适当机械性能的纤维纺丝技术和材料对于制造模仿肌肉组织结构的排列纤维支架非常重要。在此，作者报告了通过无溶剂聚合获得的热塑性聚己二酸丁二醇酯基聚氨酯弹性体的触摸纺丝。这种聚合物具有多种重要优点，例如：1）在几兆帕范围内的低弹性模量；2）良好的回复率；3）弹性；4）可加工性；5）无毒性；6）生物相容性；7）生物降解性，这些使其适合制造模仿肌肉组织细胞外基质的结构。触摸纺丝无需使用高压即可快速精确地沉积高度排列的微纤维和纳米纤维。C2C12成肌细胞很容易沿着柔软的聚合物纤维排列，并表现出高活力以及增殖能力，这使得所提出的聚合物和制造方法的组合非常适合用于工程化骨骼肌。
