Lecomte D, Vulser C, Dassier P, Cousin M T
Département d'Anesthésie-Réanimation Chirurgicale, Hôpital Broussais, Paris.
Cah Anesthesiol. 1987 Oct;35(6):465-71.
In 21 anaesthetics on patients ASA I-II undergoing middle ear microsurgery, the induction was done by 2 mg/kg propofol and 2 mcg/kg fentanyl. Anaesthesia was maintained by a continuous infusion of propofol 100 mcg/kg/min and bolus injections of fentanyl 1 mcg/kg every 30 min, and controlled ventilation with 60% Nitrous Oxide. The side effects during induction and recovery were minor. After a slight fall in blood pressure at induction, the haemodynamic values were steady during the whole surgery. Haemostasis was always good: the operating field was bloodless in 13 patients (62%), relatively bloody in 8 (38%), but never inconvenient for the surgeon. While recovery happened later than in other studies, the time from eyes opening to complete consciousness was always short, less than 10 minutes. The adjunction of fentanyl could be responsible for the long recovery time. No correlation is found between the infusion rate of propofol and recovery time. All patients but one are satisfied with their anaesthesia, especially with their smooth recovery.
在对21例美国麻醉医师协会（ASA）分级为I-II级且正在接受中耳显微手术的患者进行的麻醉过程中，诱导麻醉采用2mg/kg丙泊酚和2μg/kg芬太尼。麻醉维持采用持续输注100μg/kg/min的丙泊酚以及每30分钟静脉推注1μg/kg的芬太尼，并使用60%氧化亚氮进行控制通气。诱导和苏醒过程中的副作用较小。诱导时血压略有下降后，整个手术过程中的血流动力学值保持稳定。止血效果一直良好：13例患者（62%）术野无血，8例（38%）相对有血，但对手术医生来说都不造成不便。虽然苏醒时间比其他研究中要晚，但从睁眼到完全清醒的时间始终很短，不到10分钟。芬太尼的添加可能是苏醒时间长的原因。未发现丙泊酚输注速率与苏醒时间之间存在相关性。除1例患者外，所有患者对其麻醉效果，尤其是平稳的苏醒过程都很满意。
