Danel O, Luccioni G, Renard C, Normand S, Duvaldestin P
Cah Anesthesiol. 1987 Mar-Apr;35(2):129-32.
The use of propofol for induction and maintenance of anaesthesia was investigated in 77 patients undergoing orthopedic surgery scheduled to last no longer than 1 h. General anaesthesia is induced with 2 mg X kg-1 propofol, and maintained with repeated bolus of half induction dose of propofol (given when anaesthesia is judged too light). Anaesthesia was successfully induced with the single dose of propofol 2 mg X kg-1 in 93% patients, the others needed additional bolus dose of 1 to 2 mg X kg-1. For maintenance, mean rate of propofol was 0.148 mg X kg-1 X min-1. The recovery time was 15 minutes after the last bolus of propofol. The most noticeable side effects were apnoea during induction (89%), and painful injection (35%). Propofol is a short acting intravenous anaesthetic devoided of serious side effect which appears very useful for day case surgery.
在77例计划进行时长不超过1小时的骨科手术患者中，研究了丙泊酚用于麻醉诱导和维持的情况。全身麻醉诱导采用2mg/kg丙泊酚，维持采用重复推注半诱导剂量丙泊酚（在判断麻醉过浅时给予）。93%的患者单次给予2mg/kg丙泊酚成功诱导麻醉，其他患者需要额外推注1至2mg/kg剂量。维持麻醉时，丙泊酚平均给药速率为0.148mg/kg/min。最后一次推注丙泊酚后恢复时间为15分钟。最显著的副作用是诱导期呼吸暂停（89%）和注射痛（35%）。丙泊酚是一种短效静脉麻醉药，无严重副作用，对日间手术似乎非常有用。
