Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Clin Nutr. 2022 Feb;41(2):452-459. doi: 10.1016/j.clnu.2021.12.033. Epub 2021 Dec 28.
Evidence for a role of single nutrition or foods on ovarian cancer (OC) survival has been limited and inconclusive. Due to the potentially complex interactions in dietary, we applied dietary patterns to this study to firstly explore the relationship between the pre-diagnosis overall diet and OC survival.
The prospective cohort study was conducted among 853 OC patients aged 18-79 years during 2015-2020. Dietary intake was collected using a validated 111-item food frequency questionnaire. Deaths were obtained by medical records and cancer registry up to March 31, 2021. Cox proportional hazards regression models was used to evaluate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of pre-diagnosis dietary patterns with overall survival (OS).
Overall, during the follow-up period (median: 37.57 months, interquartile: 25.00-50.17 months), 130 (18.49%) OC patients died. Four dietary patterns were identified: healthy pattern, ethnic pattern, animal foods pattern, and sweet pattern. The highest tertile of the healthy pattern scores was related to better OS compared with the lowest tertile scores (HR = 0.54, 95% CI = 0.30-0.98, p trend <0.05), whereas OC patients with highest adherence to the animal foods pattern was associated with worse OS than those with the lowest adherence (HR = 1.90, 95% CI = 1.14-3.17, p trend <0.05). We found no significant associations between adherence to ethnic pattern and sweet pattern and OS of OC patients.
Pre-diagnosis healthy patterns was associated with better OC survival, whereas animal pattern was associated with worse survival among OC survivals.
单一营养素或食物对卵巢癌（OC）生存的影响的证据有限且不确定。由于饮食中存在潜在的复杂相互作用，我们将饮食模式应用于本研究中，首先探讨了诊断前整体饮食与 OC 生存之间的关系。
这项前瞻性队列研究于 2015 年至 2020 年期间在 853 名年龄在 18-79 岁的 OC 患者中进行。使用经过验证的 111 项食物频率问卷收集饮食摄入信息。通过病历和癌症登记处获取截至 2021 年 3 月 31 日的死亡信息。使用 Cox 比例风险回归模型评估诊断前饮食模式与总生存（OS）之间的关联的风险比（HR）和 95%置信区间（CI）。
总的来说，在随访期间（中位数：37.57 个月，四分位距：25.00-50.17 个月），有 130 名（18.49%）OC 患者死亡。确定了四种饮食模式：健康模式、民族模式、动物食品模式和甜食模式。与最低三分位分数相比，健康模式分数最高三分位的患者 OS 更好（HR=0.54，95%CI=0.30-0.98，p 趋势<0.05），而最高三分位分数的 OC 患者与最低三分位分数的患者相比，动物食品模式的依从性与更差的 OS 相关（HR=1.90，95%CI=1.14-3.17，p 趋势<0.05）。我们发现 OC 患者对民族模式和甜食模式的依从性与 OS 之间没有显著关联。
诊断前的健康模式与 OC 生存的改善相关，而动物模式与 OC 生存者的生存较差相关。
Zotero 插件