Department of Biomass Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Department of Biomass Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China; BMI Center for Biomass Materials and Nanointerfaces, College of Biomass Science and Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
J Hazard Mater. 2022 Apr 15;428:128145. doi: 10.1016/j.jhazmat.2021.128145. Epub 2022 Jan 3.
Designing a hemoperfusion adsorbent for the excretion therapy of toxic heavy metals still remains a great challenge due to the biosafety risks of non-biological materials and the desired highly efficient removal capacity. Herein, inspired from the homeostasis mechanism of plants, natural polyphenols are integrated with collagen matrix to construct a polyphenol-functionalized collagen-based artificial liver (PAL) for heavy metals excretion and free radicals scavenging therapy. PAL presents high adsorption capacities for Cu, Pb, and UO ions, up to 76.98 μmol g, 106.70 μmol g, and 252.48 μmol g, respectively. Remarkably, PAL possesses a high binding affinity for UO, Pb, and Cu ions even in the complex serum environment with the presence of biologically-relevant ions (e.g., Mg, Ca ions). Low hemolysis ratio (1.77%), high cell viability (> 85%), high plasma recalcification time (17.4 min), and low protein adsorption (1.02 μmol g) indicate outstanding biocompatibility of this material. This natural polyphenol/collagen-based fully bio-derived hemoperfusion adsorbent provides a novel and potentially applicable strategy for constructing a hemoperfusion adsorbent for heavy metal ions excretion therapy with efficiency and biosafety.
由于非生物材料的生物安全性风险和所需的高效去除能力，设计用于排泄治疗毒性重金属的血液灌流吸附剂仍然是一个巨大的挑战。受植物体内平衡机制的启发，将天然多酚与胶原基质结合，构建了一种多酚功能化胶原基人工肝（PAL），用于重金属排泄和自由基清除治疗。PAL 对 Cu、Pb 和 UO 离子表现出高吸附能力，分别高达 76.98 μmol g、106.70 μmol g 和 252.48 μmol g。值得注意的是，PAL 对 UO、Pb 和 Cu 离子具有高结合亲和力，即使在含有生物相关离子（如 Mg、Ca 离子）的复杂血清环境中也是如此。低溶血率（1.77%）、高细胞活力（>85%）、高血浆再钙化时间（17.4 分钟）和低蛋白吸附（1.02 μmol g）表明该材料具有出色的生物相容性。这种基于天然多酚/胶原的全生物衍生血液灌流吸附剂为构建高效、生物安全的用于重金属离子排泄治疗的血液灌流吸附剂提供了一种新颖且有潜力的策略。
