Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
Department of Pathology, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
S D Med. 2021 Nov;74(11):528-531.
Granular cell tumors (GCT) are benign, submucosal tumors derived from neural or Schwann cells. They are commonly found in the oral cavity, skin, breast and tongue. Less commonly, they can also occur in the gastrointestinal tract, usually in the esophagus. We describe two cases of esophageal GCT which were discovered by upper endoscopy (EGD). Case one underwent endoscopic ultrasound (EUS) guided fine needle aspiration and biopsy and case two underwent biopsy of a submucosal nodule. Both biopsies were histologically diagnosed as GCT with supportive S100 positive immunostaining. GCTs are an important diagnosis for physicians to consider in their differential of esophageal nodule or lesion. Though benign, they may rarely show malignant transformation. Therefore, it is essential to have surveillance with EGD/EUS every two to three years if they are not surgically resected.
颗粒细胞瘤（GCT）是一种来源于神经或施万细胞的良性黏膜下肿瘤。它们常见于口腔、皮肤、乳腺和舌。较少见的是，它们也可能发生在胃肠道，通常在食管。我们描述了两例通过上消化道内镜（EGD）发现的食管 GCT。第 1 例患者行内镜超声（EUS）引导下细针抽吸活检，第 2 例患者行黏膜下结节活检。两次活检均组织学诊断为 GCT，支持 S100 阳性免疫组化染色。GCT 是医生在鉴别食管结节或病变时需要考虑的重要诊断。虽然是良性的，但它们可能很少发生恶性转化。因此，如果不进行手术切除，每 2-3 年进行一次 EGD/EUS 监测是很有必要的。
