Krishnan Rehna, Patel Parasvi S, Hakem Razqallah
Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
Cancers (Basel). 2021 Dec 27;14(1):108. doi: 10.3390/cancers14010108.
Heritable mutations in and genes are a major risk factor for breast and ovarian cancer. Inherited mutations in increase the risk of developing breast cancers by up to 72% and ovarian cancers by up to 69%, when compared to individuals with wild-type . and () are both important for homologous recombination-mediated DNA repair. The link between mutations and high susceptibility to breast cancer is well established. However, the potential impact of mutation on the individual cell populations within a tumor microenvironment, and its relation to increased aggressiveness of cancer is not well understood. The objective of this review is to provide significant insights into the mechanisms by which mutations contribute to the metastatic and aggressive nature of the tumor cells.
BRCA1和BRCA2基因中的遗传性突变是乳腺癌和卵巢癌的主要风险因素。与野生型BRCA1个体相比，BRCA1基因的遗传性突变使患乳腺癌的风险增加高达72%，患卵巢癌的风险增加高达69%。BRCA1和BRCA2（BRCA）对于同源重组介导的DNA修复都很重要。BRCA1突变与乳腺癌高易感性之间的联系已得到充分证实。然而，BRCA2突变对肿瘤微环境内单个细胞群体的潜在影响及其与癌症侵袭性增加的关系尚未得到充分了解。本综述的目的是深入了解BRCA2突变导致肿瘤细胞转移和侵袭性的机制。
