Melin M, Saeland S, Magloire H, Hartmann D J, Guerret S, Blanchard D, Banchereau J, Grimaud J A
Laboratoire de Pathologie Cellulaire, CNRS-UA 602, Institut Pasteur, Lyon, France.
Coll Relat Res. 1987 Oct;7(5):371-81. doi: 10.1016/s0174-173x(87)80029-8.
Several studies indicate a relationship between immunocompetent cells and fibroblast functions such as proliferation and collagen synthesis, which may be of importance in understanding the process of fibrosis. We demonstrate here the activity of supernatant from an activated human CD4+ proliferative T-cell clone (2F1) in stimulating the proliferation of human dental pulp fibroblasts, while inhibiting their soluble type I collagen secretion in either growing or confluent cultures. Taken together, our results indicate that T-cell derived lymphokines may be of importance in regulating normal dental pulp fibroblast functions.
多项研究表明免疫活性细胞与成纤维细胞功能（如增殖和胶原蛋白合成）之间存在关联，这对于理解纤维化过程可能具有重要意义。我们在此证明，来自活化的人CD4 +增殖性T细胞克隆（2F1）的上清液在刺激人牙髓成纤维细胞增殖的同时，会抑制其在生长或汇合培养物中可溶性I型胶原蛋白的分泌。综上所述，我们的结果表明T细胞衍生的淋巴因子在调节正常牙髓成纤维细胞功能方面可能具有重要作用。
