Tantari Matteo, Bogliolo Stefano, Morotti Matteo, Balaya Vincent, Bouttitie Florent, Buenerd Annie, Magaud Laurent, Lecuru Fabrice, Guani Benedetta, Mathevet Patrice
Gynecology Department, Centre Hopital-Universitaire Vaudois, 1011 Lausanne, Switzerland.
Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Università degli Studi di Genova, 16128 Genoa, Italy.
Cancers (Basel). 2022 Jan 2;14(1):212. doi: 10.3390/cancers14010212.
In patients with cervical cancer, the presence of tumoral lymph-vascular space invasion (LVSI) is the main risk factor for pelvic lymph node metastasis (PLNM). The objective of this study was to evaluate the presence of several markers of lymphangiogenesis in early-stage cervical cancer and their correlation with PLNM and tumoral recurrence. Seventy-five patients with early-stage cervical carcinoma underwent sentinel lymph node (SLN) sampling in association with complete pelvic lymph node dissection. Primary tumors were stained with the following markers: Ki67, D2-40, CD31 and VEGF-C. A 3-year follow-up was performed to evaluate the disease-free survival. Overall, 14 patients (18.6%) had PLNM. Positive LVSI was seen in 29 patients (38.6%). There was a significant correlation between LVSI evidenced by H/E staining and PLNM ( < 0.001). There was no correlation between high Ki67, CD31, D2-40, and VEGF-C staining with PLNM or tumor recurrence. Our data support that lymphatic spread does not require the proliferation of new lymphatic endothelial cells in early-stage cervical cancer. These results emphasize the importance of pre-existing peritumoral lymphatic vessels in the metastatic process in early cervical cancer. None of the markers of lymphangiogenesis and proliferation assessed in this study were predictive of PLNM or recurrence.
在宫颈癌患者中，肿瘤淋巴管间隙浸润（LVSI）的存在是盆腔淋巴结转移（PLNM）的主要危险因素。本研究的目的是评估早期宫颈癌中几种淋巴管生成标志物的存在情况及其与PLNM和肿瘤复发的相关性。75例早期宫颈癌患者在进行盆腔淋巴结完全清扫术的同时接受了前哨淋巴结（SLN）取样。原发性肿瘤用以下标志物染色：Ki67、D2-40、CD31和VEGF-C。进行了3年的随访以评估无病生存期。总体而言，14例患者（18.6%）发生了PLNM。29例患者（38.6%）可见阳性LVSI。H/E染色显示的LVSI与PLNM之间存在显著相关性（<0.001）。高Ki67、CD31、D2-40和VEGF-C染色与PLNM或肿瘤复发之间无相关性。我们的数据支持在早期宫颈癌中，淋巴转移并不需要新的淋巴管内皮细胞增殖。这些结果强调了肿瘤周围预先存在的淋巴管在早期宫颈癌转移过程中的重要性。本研究中评估的淋巴管生成和增殖标志物均不能预测PLNM或复发。
