Yang Zihao, Niu Yicui, Ma Hui, Gong Wenqing, Yu Lu, Liu Liwen, Zheng Minjuan
Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Front Cardiovasc Med. 2023 Jun 8;10:1182334. doi: 10.3389/fcvm.2023.1182334. eCollection 2023.
This study aimed to explore the diagnostic value of contrast-enhanced echocardiography (CEE) in benign and malignant cardiac tumors and detect the correlation of CEE parameters and immunohistochemistry (IHC) markers.
The data of 44 patients with cardiac tumors confirmed by pathology were reviewed. Lesions were examined before surgery using transthoracic echocardiography (TTE) and CEE with time-intensity curve analysis. The expression of CD31, VEGF and Ki67 was measured by IHC staining. Microvessel density (MVD) was quantified via IHC for CD31. The clinical variables, TTE, CEE and IHC parameters were compared between benign and malignant cardiac tumors. Receiver operating characteristic curve were used to analyze the value of factors in predicting malignant cardiac tumors. The correlation between CEE and IHC parameters was analyzed.
Among 44 cardiac tumors, 34 were benign and 10 were malignant. There were significant differences in the TTE parameters (pericardial effusion, tumor boundary, diameter, basal width), CEE parameters (tumor peak intensity (TPI), peak intensity ratio of tumor to myocardium (TPI/MPI), area under time-intensity curve (AUTIC)) and IHC parameters (Ki67, MVD, CD31, VEGF) between the benign and malignant tumor groups (all < 0.05). Receiver operating characteristic curve analysis showed that the CEE and IHC parameters had diagnostic value in malignant cardiac tumors. There was a correlation between TPI/MPI and Ki67 ( = 0.62), AUTIC and Ki67 ( = 0.50), and AUTIC and CD31 ( = 0.56).
TTE and CEE parameters were different between benign and malignant cardiac tumors. CEE is helpful to differentiate the properties of cardiac tumors. There is a correlation between CEE parameters and IHC markers. AUTIC and TPI/MPI can reflect the proliferation and invasion of tumors.
本研究旨在探讨超声心动图造影（CEE）在心脏良恶性肿瘤中的诊断价值，并检测CEE参数与免疫组织化学（IHC）标志物的相关性。
回顾44例经病理确诊的心脏肿瘤患者的数据。术前采用经胸超声心动图（TTE）和CEE并进行时间-强度曲线分析检查病变。通过IHC染色检测CD31、VEGF和Ki67的表达。通过对CD31进行IHC定量微血管密度（MVD）。比较心脏良恶性肿瘤之间的临床变量、TTE、CEE和IHC参数。采用受试者工作特征曲线分析各因素在预测心脏恶性肿瘤中的价值。分析CEE与IHC参数之间的相关性。
44例心脏肿瘤中，34例为良性，10例为恶性。良性和恶性肿瘤组之间的TTE参数（心包积液、肿瘤边界、直径、基底宽度）、CEE参数（肿瘤峰值强度（TPI）、肿瘤与心肌峰值强度比（TPI/MPI）、时间-强度曲线下面积（AUTIC））和IHC参数（Ki67、MVD、CD31、VEGF）存在显著差异（均<0.05）。受试者工作特征曲线分析表明，CEE和IHC参数对心脏恶性肿瘤具有诊断价值。TPI/MPI与Ki67（=0.62）、AUTIC与Ki67（=0.50）以及AUTIC与CD31（=0.56）之间存在相关性。
心脏良恶性肿瘤之间的TTE和CEE参数不同。CEE有助于鉴别心脏肿瘤的性质。CEE参数与IHC标志物之间存在相关性。AUTIC和TPI/MPI可反映肿瘤的增殖和侵袭情况。
