Camacho Laura, Ouro Alberto, Gomez-Larrauri Ana, Carracedo Arkaitz, Gomez-Muñoz Antonio
Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), 48080 Bilbao, Spain.
Center for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48160 Derio, Spain.
Cancers (Basel). 2022 Jan 4;14(1):227. doi: 10.3390/cancers14010227.
Cancer cells rewire their metabolic programs to favor biological processes that promote cell survival, proliferation, and dissemination. Among this relevant reprogramming, sphingolipid metabolism provides metabolites that can favor or oppose these hallmarks of cancer. The sphingolipid ceramide 1-phosphate (C1P) and the enzyme responsible for its biosynthesis, ceramide kinase (CERK), are well established regulators of cell growth and survival in normal, as well as malignant cells through stress-regulated signaling pathways. This metabolite also promotes cell survival, which has been associated with the feedback regulation of other antitumoral sphingolipids or second messengers. C1P also regulates cancer cell invasion and migration of different types of cancer, including lung, breast, pancreas, prostate, or leukemia cells. More recently, CERK and C1P have been implicated in the control of inflammatory responses. The present review provides an updated view on the important role of CERK/C1P in the regulation of cancer cell growth, survival, and dissemination.
癌细胞会重新调整其代谢程序，以支持那些促进细胞存活、增殖和扩散的生物学过程。在这种相关的重编程过程中，鞘脂代谢产生的代谢产物既能促进也能对抗癌症的这些特征。鞘脂类神经酰胺1-磷酸（C1P）及其生物合成酶神经酰胺激酶（CERK），通过应激调节信号通路，是正常细胞以及恶性细胞中细胞生长和存活的既定调节因子。这种代谢产物还能促进细胞存活，这与其他抗肿瘤鞘脂或第二信使的反馈调节有关。C1P还能调节不同类型癌症（包括肺癌、乳腺癌、胰腺癌、前列腺癌或白血病细胞）的癌细胞侵袭和迁移。最近，CERK和C1P还参与了炎症反应的控制。本综述提供了关于CERK/C1P在调节癌细胞生长、存活和扩散方面重要作用的最新观点。
