Popova Nadezhda V, Jücker Manfred
Laboratory of Receptor Cell Biology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Str., 16/10, 117997 Moscow, Russia.
Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany.
Cancers (Basel). 2022 Jan 4;14(1):238. doi: 10.3390/cancers14010238.
The extracellular matrix (ECM) is highly dynamic as it is constantly deposited, remodeled and degraded to maintain tissue homeostasis. ECM is a major structural component of the tumor microenvironment, and cancer development and progression require its extensive reorganization. Cancerized ECM is biochemically different in its composition and is stiffer compared to normal ECM. The abnormal ECM affects cancer progression by directly promoting cell proliferation, survival, migration and differentiation. The restructured extracellular matrix and its degradation fragments (matrikines) also modulate the signaling cascades mediated by the interaction with cell-surface receptors, deregulate the stromal cell behavior and lead to emergence of an oncogenic microenvironment. Here, we summarize the current state of understanding how the composition and structure of ECM changes during cancer progression. We also describe the functional role of key proteins, especially tenascin C and fibronectin, and signaling molecules involved in the formation of the tumor microenvironment, as well as the signaling pathways that they activate in cancer cells.
细胞外基质（ECM）具有高度动态性，因为它不断地沉积、重塑和降解以维持组织稳态。ECM是肿瘤微环境的主要结构成分，癌症的发生和发展需要其广泛的重组。癌化的ECM在组成上具有生化差异，并且比正常ECM更硬。异常的ECM通过直接促进细胞增殖、存活、迁移和分化来影响癌症进展。重组的细胞外基质及其降解片段（基质因子）还通过与细胞表面受体相互作用介导的信号级联反应进行调节，使基质细胞行为失调，并导致致癌微环境的出现。在这里，我们总结了目前对癌症进展过程中ECM的组成和结构如何变化的理解现状。我们还描述了关键蛋白，特别是纤连蛋白和纤连蛋白，以及参与肿瘤微环境形成的信号分子的功能作用，以及它们在癌细胞中激活的信号通路。
Zotero 插件
