细胞外囊泡介导的癌症相关成纤维细胞与肿瘤之间的串扰

Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors.

作者信息

He Chuanshi, Wang Linlin, Li Ling, Zhu Guiquan

机构信息

Department of Stomatology, Sichuan Cancer Hospital, Sichuan Key Laboratory of Radiation Oncology, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section 3, Renmin South Road, Chengdu, Sichuan 610041, China.

出版信息

Transl Oncol. 2021 Dec;14(12):101231. doi: 10.1016/j.tranon.2021.101231. Epub 2021 Oct 1.

DOI:10.1016/j.tranon.2021.101231

PMID:34601397

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8493591/

Abstract

Communication networks in the tumor microenvironment (TME) play a crucial role in tumor progression. Cancer-associated fibroblasts (CAFs) are among the most abundant stromal cells in the TME. Bidirectional signal transduction between cancer cells and CAFs within the TME is important for cancer development and treatment responsiveness. Extracellular vesicles (EVs) carrying proteins, miRNAs, and other biomolecules are secreted into the extracellular matrix (ECM), which has been demonstrated to be an important communication medium between tumors and CAFs. Tumors regulate the activation of CAFs by secreting EVs. Conversely, CAFs can also affect tumor proliferation, metastasis, and therapeutic resistance through EVs. Here, we will classify EV cargoes and discuss the role of EV-mediated interactions between CAFs and tumors, reviewing current knowledge in combination with our confirmed results.

摘要

肿瘤微环境（TME）中的通讯网络在肿瘤进展中起着关键作用。癌症相关成纤维细胞（CAF）是TME中最丰富的基质细胞之一。TME内癌细胞与CAF之间的双向信号转导对癌症发展和治疗反应性很重要。携带蛋白质、微小RNA（miRNA）和其他生物分子的细胞外囊泡（EV）被分泌到细胞外基质（ECM）中，ECM已被证明是肿瘤与CAF之间的重要通讯介质。肿瘤通过分泌EV来调节CAF的激活。相反，CAF也可以通过EV影响肿瘤增殖、转移和治疗抗性。在这里，我们将对EV货物进行分类，并讨论EV介导的CAF与肿瘤之间相互作用的作用，结合我们已证实的结果回顾当前的知识。