Baldwin C L, Teale A J
International Laboratory for Research on Animal Diseases, Nairobi, Kenya.
Eur J Immunol. 1987 Dec;17(12):1859-62. doi: 10.1002/eji.1830171230.
Theileria parva is a protozoan parasite which infects and transforms bovine lymphocytes. This study examined the effects of Theileria-induced transformation on phenotype and function, in terms of cytolytic potency and specificity, of class I and class II-specific alloreactive T cell clones. Alloreactive T cell clones infected with T. parva (Muguga) retained expression of the T cell differentiation antigens BoT2, BoT4, BoT8 and the mature T cell antigen recognized by monoclonal antibody IL-A27, as well as cytolytic function and antigen specificity, over a period of 3-4 months in continuous culture. These features were identical to those expressed by the uninfected parent clones. During this period, neither antigenic stimulation nor exogenous growth factors were required for the maintenance of proliferation, function or antigen specificity. Thereafter, cytolytic activity declined and was eventually lost, which may reflect degenerative changes normally associated with T cell senescence rather than result from parasitization per se.
小泰勒虫是一种感染并转化牛淋巴细胞的原生动物寄生虫。本研究从细胞溶解效力和特异性方面，考察了小泰勒虫诱导的转化对I类和II类特异性同种异体反应性T细胞克隆的表型和功能的影响。感染了小泰勒虫（穆古加株）的同种异体反应性T细胞克隆，在连续培养3 - 4个月的时间里，保留了T细胞分化抗原BoT2、BoT4、BoT8以及单克隆抗体IL - A27识别的成熟T细胞抗原的表达，以及细胞溶解功能和抗原特异性。这些特征与未感染的亲本克隆所表达的特征相同。在此期间，维持增殖、功能或抗原特异性既不需要抗原刺激，也不需要外源性生长因子。此后，细胞溶解活性下降并最终丧失，这可能反映了通常与T细胞衰老相关的退行性变化，而非由寄生虫感染本身导致。
