Türker Cihan, Emre Elif, Aydın Süleyman, Dalgıç Mustafa, Baklacı Deniz
Department of Otolaryngology, Private Medical Hospital, Elazig 23040, Turkey.
Department of Anatomy, Firat University Faculty of Medicine, Elazig 23200, Turkey.
Medicina (Kaunas). 2025 Apr 18;61(4):747. doi: 10.3390/medicina61040747.
: This study aimed to examine the relationship between serum calprotectin levels and facial paralysis in patients with Bell's palsy and to determine its prognostic significance. : This study included 40 patients diagnosed with Bell's palsy and 20 healthy individuals as controls. The patients were categorized into three groups based on their response to treatment: complete response, partial response, and no response. Blood samples were taken before treatment and in the third month after treatment to measure C-reactive protein, white blood cell count, lymphocyte count, neutrophil count, neutrophil-to-lymphocyte ratio, and calprotectin levels. : Serum calprotectin levels were found to be elevated in patients with BP compared to the healthy controls; however, no significant correlation was observed between calprotectin levels and disease prognosis. : The findings suggest that Bell's palsy patients have elevated serum calprotectin levels compared to healthy individuals, indicating the potential use of calprotectin as a biomarker in Bell's palsy. However, no significant difference in calprotectin levels was observed between patients with varying degrees of treatment response, suggesting that calprotectin may be limited in predicting disease prognosis.
本研究旨在探讨贝尔麻痹患者血清钙卫蛋白水平与面瘫之间的关系，并确定其预后意义。本研究纳入了40例诊断为贝尔麻痹的患者和20例健康个体作为对照。根据患者对治疗的反应将其分为三组：完全缓解、部分缓解和无反应。在治疗前和治疗后第三个月采集血样，以测量C反应蛋白、白细胞计数、淋巴细胞计数、中性粒细胞计数、中性粒细胞与淋巴细胞比值以及钙卫蛋白水平。与健康对照相比，贝尔麻痹患者的血清钙卫蛋白水平升高；然而，未观察到钙卫蛋白水平与疾病预后之间存在显著相关性。研究结果表明，与健康个体相比，贝尔麻痹患者的血清钙卫蛋白水平升高，这表明钙卫蛋白有可能作为贝尔麻痹的生物标志物。然而，不同治疗反应程度的患者之间钙卫蛋白水平未观察到显著差异，这表明钙卫蛋白在预测疾病预后方面可能存在局限性。
