SIRT3 介导的线粒体动态平衡在骨关节炎中的作用。
The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis.
机构信息
Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
出版信息
Cell Mol Life Sci. 2020 Oct;77(19):3729-3743. doi: 10.1007/s00018-020-03497-9. Epub 2020 May 28.
Abstract
Osteoarthritis is the most common degenerative joint disease and causes major pain and disability in adults. It has been reported that mitochondrial dysfunction in chondrocytes is associated with osteoarthritis. Sirtuins are a family of nicotinamide adenine dinucleotide-dependent histone deacetylases that have the ability to deacetylate protein targets and play an important role in the regulation of cell physiological and pathological processes. Among sirtuin family members, sirtuin 3, which is mainly located in mitochondria, can exert its deacetylation activity to regulate mitochondrial function, regeneration, and dynamics; these processes are presently recognized to maintain redox homeostasis to prevent oxidative stress in cell metabolism. In this review, we provide present opinions on the effect of mitochondrial dysfunction in osteoarthritis. Furthermore, the potential protective mechanism of SIRT3-mediated mitochondrial homeostasis in the progression of osteoarthritis is discussed.
摘要
骨关节炎是最常见的退行性关节疾病，会给成年人带来严重的疼痛和残疾。据报道，软骨细胞中线粒体功能障碍与骨关节炎有关。沉默调节蛋白是烟酰胺腺嘌呤二核苷酸依赖性组蛋白去乙酰化酶家族，具有去乙酰化蛋白靶标的能力，在调节细胞生理和病理过程中发挥重要作用。在沉默调节蛋白家族成员中，主要位于线粒体中的沉默调节蛋白 3 可以发挥其去乙酰化活性来调节线粒体功能、再生和动力学；这些过程目前被认为是维持氧化还原平衡，以防止细胞代谢中的氧化应激。在这篇综述中，我们提供了对骨关节炎中线粒体功能障碍影响的最新观点。此外，还讨论了 SIRT3 介导的线粒体动态平衡在骨关节炎进展中的潜在保护机制。
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