Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora Street, 210026 Vitebsk, Belarus.
AP Avtsyn Research Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia.
Int J Mol Sci. 2021 Dec 31;23(1):460. doi: 10.3390/ijms23010460.
Thyroid cancer (TC) is the most common type of endocrine malignancy. Tumour formation, progression, and metastasis greatly depend on the efficacy of mitochondria-primarily, the regulation of mitochondria-mediated apoptosis, Ca homeostasis, dynamics, energy production, and associated reactive oxygen species generation. Recent studies have successfully confirmed the mitochondrial aetiology of thyroid carcinogenesis. In this review, we focus on the recent progress in understanding the molecular mechanisms of thyroid cancer relating to altered mitochondrial metabolism. We also discuss the repurposing of known drugs and the induction of mitochondria-mediated apoptosis as a new trend in the development of anti-TC therapy.
甲状腺癌（TC）是最常见的内分泌恶性肿瘤。肿瘤的形成、进展和转移在很大程度上取决于线粒体的功效，主要是线粒体介导的细胞凋亡、钙稳态、动力学、能量产生和相关活性氧生成的调节。最近的研究成功证实了甲状腺癌发生中线粒体的病因。在这篇综述中，我们重点介绍了近年来在理解与改变的线粒体代谢相关的甲状腺癌分子机制方面的进展。我们还讨论了已知药物的再利用和线粒体介导的细胞凋亡的诱导作为开发抗 TC 治疗的新趋势。
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