Meena Varsha, Sharma Shivani, Kaur Gazaldeep, Singh Bhupinder, Pandey Ajay Kumar
Department of Biotechnology, National Agri-Food Biotechnology Institute, Sector 81, Sahibzada Ajit Singh Nagar 140306, India.
Regional Centre for Biotechnology, Faridabad 121001, India.
Plants (Basel). 2021 Dec 30;11(1):102. doi: 10.3390/plants11010102.
The major facilitator superfamily (MFS) is a large and diverse group of secondary transporters found across all kingdoms of life. Zinc-induced facilitator-like (ZIFL) transporters are the MFS family members that function as exporters driven by the antiporter-dependent processes. The presence of multiple ZIFL transporters was shown in various plant species, as well as in bryophytes. However, only a few ZIFLs have been functionally characterized in plants, and their localization has been suggested to be either on tonoplast or at the plasma membrane. A subset of the plant ZIFLs were eventually characterized as transporters due to their specialized role in phytosiderophores efflux and auxin homeostasis, and they were also proven to impart tolerance to micronutrient deficiency. The emerging functions of ZIFL proteins highlight their role in addressing important traits in crop species. This review aims to provide insight into and discuss the importance of plant ZIFL in various tissue-specific functions. Furthermore, a spotlight is placed on their role in mobilizing essential micronutrients, including iron and zinc, from the rhizosphere to support plant survival. In conclusion, in this paper, we discuss the functional redundancy of ZIFL transporters to understand their roles in developing specific traits in crop.
主要易化子超家族（MFS）是一类广泛存在于所有生命王国中的庞大且多样的次级转运蛋白。锌诱导易化子样（ZIFL）转运蛋白是MFS家族成员，其功能是作为由反向转运蛋白依赖过程驱动的外排转运蛋白。多种ZIFL转运蛋白已在各种植物物种以及苔藓植物中被发现。然而，在植物中仅有少数ZIFL转运蛋白的功能得到了表征，并且它们的定位被认为要么在液泡膜上，要么在质膜上。由于植物ZIFL转运蛋白在植物高铁载体外排和生长素稳态中具有特殊作用，其一部分最终被表征为转运蛋白，并且它们也被证明能赋予植物对微量营养素缺乏的耐受性。ZIFL蛋白新出现的功能凸显了它们在解决作物重要性状方面的作用。本综述旨在深入探讨并讨论植物ZIFL在各种组织特异性功能中的重要性。此外，重点关注了它们在从根际动员包括铁和锌在内的必需微量营养素以支持植物存活方面的作用。总之，在本文中，我们讨论了ZIFL转运蛋白的功能冗余性，以了解它们在作物特定性状发育中的作用。
